No association between alpha-1-antichymotrypsin polymorphism and Alzheimer's disease in Chinese

被引：9
作者：
Wang, YC
Liu, TY
Liu, HC
Chi, CW
Sim, CB
Tsai, SJ
Hong, CJ
机构：
[1] Vet Gen Hosp, Dept Psychiat, Sec 2, Taipei 11217, Taiwan
[2] Vet Gen Hosp, Dept Med Res & Educ, Taipei 11217, Taiwan
[3] Vet Gen Hosp, Dept Neurol, Taipei 11217, Taiwan
[4] Natl Yang Ming Univ, Sch Med, Taipei 112, Taiwan
[5] Provis Chia Nan Psychiat Ctr, Tainan, Taiwan
来源：
NEUROPSYCHOBIOLOGY | 1999年 / 40卷 / 02期
关键词：
Alzheimer's disease; apolipoprotein E; alpha-1-antichymotrypsin; polymorphism;
D O I：
10.1159/000026599
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
A recent observation has shown that a common polymorphism in the alpha 1-antichymotrypsin (ACT) confers a significant risk for Alzheimer's disease (AD), Furthermore, the apolipoprotein E epsilon 4 allele (APOE*4) effect associated with AD risk is modified by the ACT polymorphisms, To evaluate the role of ACT polymorphism in AD, we conducted an association study of ACT polymorphisms in Chinese AD patients and normal controls. We found that the ACT polymorphism had no effect on the development of AD either alone or in combination with the APOE*4 allele.
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收藏
页码：67 / 70
页数：4
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