Difference in levels of SARS-CoV-2 S1 and S2 subunits- and nucleocapsid protein-reactive SIgM/IgM, IgG and SIgA/IgA antibodies in human milk

被引：76

作者：

Demers-Mathieu, Veronique ^{[1
,2
]}

Dung, M. ^{[1
]}

Mathijssen, Gabrielle B. ^{[1
]}

Sela, David A. ^{[2
]}

Seppo, Antti ^{[3
]}

Jarvinen, Kirsi M. ^{[3
]}

Medo, Elena ^{[1
]}

机构：

[1] Medolac Labs, Dept Neonatal Immunol & Microbiol, Boulder City, NV 89005 USA

[2] Univ Massachusetts Amherst, Dept Food Sci, Amherst, MA 01003 USA

[3] Univ Rochester, Med Ctr, Dept Pediat, Pediat Allergy Immunol, Rochester, NY 14642 USA

来源：

JOURNAL OF PERINATOLOGY | 2021年 / 41卷 / 04期

关键词：

POLYREACTIVE ANTIBODIES; MONOMERIC IGA; DIPHTHERIA; TETANUS; SARS; IMMUNIZATION; PROTECTION; PREGNANCY; VACCINE;

D O I：

10.1038/s41372-020-00805-w

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Objective This study evaluated the presence and the levels of antibodies reactive to SARS-CoV-2 S1 and S2 subunits (S1 + S2), and nucleocapsid protein. Study design The levels of SARS-CoV-2 S1 + S2- and nucleocapsid-reactive SIgM/IgM, IgG and SIgA/IgA were measured in human milk samples from 41 women during the COVID-19 pandemic (2020-HM) and from 16 women 2 years prior to the outbreak (2018-HM). Results SARS-CoV-2 S1 + S2-reactive SIgA/IgA, SIgM/IgM and IgG were detected in 97.6%, 68.3% and 58.5% in human milk whereas nucleocapsid-reactive antibodies were detected in 56.4%, 87.2% and 46.2%, respectively. S1 + S2-reactive IgG was higher in milk from women that had symptoms of viral respiratory infection(s) during the last year than in milk from women without symptom. S1 + S2- and nucleocapsid-reactive IgG were higher in the 2020-HM group compared to the 2018-HM group. Conclusions The presence of SARS-CoV-2-reactive antibodies in human milk could provide passive immunity to breastfed infants and protect them against COVID-19 diseases.

引用

页码：850 / 859

页数：10

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