microRNA and transcription factor mediated regulatory network for ovarian cancer Regulatory network of ovarian cancer

被引：9

作者：

Ying, Huanchun ^{[1
]}

Lv, Jing ^{[2
]}

Ying, Tianshu ^{[1
]}

Li, Jun ^{[1
]}

Yang, Qing ^{[1
]}

Ma, Yuan ^{[3
]}

机构：

[1] China Med Univ, Shengjing Hosp, Dept Gynecol & Obstet, Shenyang 110004, Liaoning Provin, Peoples R China

[2] Fifth Hosp Shenyang, Dept Oncol, Shenyang 110023, Peoples R China

[3] Anyang Tumor Hosp, Dept Gynecol 1, Anyang 455000, Hennan Province, Peoples R China

来源：

TUMOR BIOLOGY | 2013年 / 34卷 / 05期

基金：

上海市科技启明星计划;

关键词：

Ovarian cancer; Differentially expressed genes; MicroRNA; Transcription factor; Target genes; Interaction network; CELL-CYCLE ARREST; DOWN-REGULATION; EXPRESSION; FAMILY; PROLIFERATION; P21; OVEREXPRESSION; GENE;

D O I：

10.1007/s13277-013-0892-y

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A better understanding on the regulatory interactions of microRNA (miRNA) target genes and transcription factor (TF) target genes in ovarian cancer may be conducive for developing early diagnosis strategy. Thus, gene expression data and miRNA expression data were downloaded from The Cancer Genome Atlas in this study. Differentially expressed genes and miRNAs were selected out with t test, and Gene Ontology enrichment analysis was performed with DAVID tools. Regulatory interactions were retrieved from miRTarBase, TRED, and TRANSFAC, and then networks for miRNA target genes and TF target genes were constructed to globally present the mechanisms. As a result, a total of 1,939 differentially expressed genes were identified, and they were enriched in 28 functions, among which cell cycle was affected to the most degree. Besides, 213 differentially expressed miRNAs were identified. Two regulatory networks for miRNA target genes and TF target genes were established and then both were combined, in which E2F transcription factor 1, cyclin-dependent kinase inhibitor 1A, cyclin E1, and miR-16 were the hub genes. These genes may be potential biomarkers for ovarian cancer.

引用

页码：3219 / 3225

页数：7

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