Topical treatments for skin cancer

被引:128
作者
Cullen, Jason K. [1 ,3 ]
Simmons, Jacinta L. [2 ,4 ]
Parsons, Peter G. [1 ,3 ]
Boyle, Glen M. [2 ,3 ,4 ]
机构
[1] QIMR Berghofer Med Res Inst, Drug Discovery Grp, Brisbane, Qld, Australia
[2] QIMR Berghofer Med Res Inst, Canc Drug Mech Grp, Brisbane, Qld, Australia
[3] Univ Queensland, Sch Biomed Sci, Fac Med, Brisbane, Qld, Australia
[4] Queensland Univ Technol, Fac Hlth, Sch Biomed Sci, Brisbane, Qld, Australia
基金
英国医学研究理事会;
关键词
Actinic keratosis; Basal cell carcinoma; Squamous cell carcinoma; Lentigo maligna; Melanoma; Topical therapy; BASAL-CELL CARCINOMA; INGENOL MEBUTATE GEL; IMIQUIMOD 5-PERCENT CREAM; AMINOLEVULINATE PHOTODYNAMIC THERAPY; ACTINIC KERATOSIS; DOUBLE-BLIND; LENTIGO MALIGNA; METHYL AMINOLEVULINATE; BOWENS-DISEASE; IN-SITU;
D O I
10.1016/j.addr.2019.11.002
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Skin cancer is a broad term used to describe a number of different malignant indications of the skin. Skin cancers mostly comprise of the keratinocyte cancers [Basal Cell Carcinoma (BCC) and cutaneous Squamous Cell Carcinoma (SCC)], and melanoma. Surgical excision of these malignancies has been the preferred treatment of patients for decades. However, the decision to perform surgery can be affected by various considerations, including co-morbidities of the patient, the anatomical site of the lesion and potential intolerance for repeated excisions. Topical treatment of skin cancer may therefore be more appropriate in certain instances. Topical treatment potentially allows for higher drug levels at the tumor site, and may result in less overall toxicity than systemic agents. This review will specifically address the current agents used in topical treatment of skin cancers, and introduce emerging treatments from the natural product field that may also find utility in these indications. (c) 2019 Elsevier B.V. All rights reserved.
引用
收藏
页码:54 / 64
页数:11
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