Use of the potassium ion as a template for the selective derivatization of the antibiotic X-206

被引：9

作者：

O'Sullivan, AC

Struber, F ^{[1
]}

Ley, SV

机构：

[1] Novartis AG, CH-4002 Basel, Switzerland

[2] Univ Cambridge, Dept Chem, Cambridge CB2 1EW, England

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1999年 / 64卷 / 17期

关键词：

D O I：

10.1021/jo9903151

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The templating effect of potassium ions on the ionophore antibiotic X-206 (1) ensured that most of the hydroxy, hemiacetal, and ether groups were involved in encapsulation of the metal atom, which allowed a selective derivatization at the unbound C(22) position. The mechanism of acylation at, C(22) was investigated and the aquired knowledge used to achieve selective reactions on the benzyl ester 8 using a similar metal template protection.

引用

页码：6252 / 6256

页数：5

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