The ageing immune system: is it ever too old to become young again?

被引：303

作者：

Dorshkind, Kenneth ^{[1
]}

Montecino-Rodriguez, Encarnacion ^{[1
]}

Signer, Robert A. J. ^{[1
]}

机构：

[1] Univ Calif Los Angeles, David Geffen Sch Med, Dept Pathol & Lab Med, Los Angeles, CA 90095 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2009年 / 9卷 / 01期

基金：

美国国家卫生研究院;

关键词：

AGE-RELATED-CHANGES; BONE-MARROW; T-CELLS; CALORIC RESTRICTION; INFLUENZA VACCINES; STEM-CELLS; B-CELLS; SENESCENCE; CANCER; MICE;

D O I：

10.1038/nri2471

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Ageing is accompanied by a decline in the function of the immune system, which increases susceptibility to infections and can decrease the quality of life. The ability to rejuvenate the ageing immune system would therefore be beneficial for elderly individuals and would decrease health-care costs for society. But is the immune system ever too old to become young again? We review here the promise of various approaches to rejuvenate the function of the immune system in the rapidly growing ageing population.

引用

页码：57 / 62

页数：6

共 61 条

[51] Aging and cancer resistance in lymphoid progenitors are linked processes conferred by p16Ink4a and Arf [J].

Signer, Robert A. J. ;

Montecino-Rodriguez, Encarnacion ;

Witte, Owen N. ;

Dorshkind, Kenneth .

GENES & DEVELOPMENT, 2008, 22 (22) :3115-3120

[52]

Steinmann G G, 1986, Curr Top Pathol, V75, P43

[53] Stem cells - A new route to rejuvenation [J].

Surani, M. Azim ;

McLaren, Anne .

NATURE, 2006, 443 (7109) :284-285

[54] Enhanced immune system regeneration in humans following allogeneic or autologous hemopoietic stem cell transplantation by temporary sex steroid blockade [J].

Sutherland, Jayne S. ;

Spyroglou, Lisa ;

Muirhead, Jennifer L. ;

Heng, Tracy S. ;

Prieto-Hinojosa, Adria ;

Prince, H. Miles ;

Chidgeyl, Ann P. ;

Schwarer, Anthony P. ;

Boyd, Richard L. .

CLINICAL CANCER RESEARCH, 2008, 14 (04) :1138-1149

[55]

TRZONKOWSKI P, 2008, BIOGERENTOLOGY 0619, DOI DOI 10.1007/S10522-008-9155-9155

[56] Aged mice exhibit distinct B cell precursor phenotypes differing in activation, proliferation and apoptosis [J].

Van der Put, E ;

Sherwood, EM ;

Blomberg, BB ;

Riley, RL .

EXPERIMENTAL GERONTOLOGY, 2003, 38 (10) :1137-1147

[57] Puzzles, promises and a cure for ageing [J].

Vijg, Jan ;

Campisi, Judith .

NATURE, 2008, 454 (7208) :1065-1071

[58] Human embryonic stem cell-derived CD34+ cells:: efficient production in the coculture with OP9 stromal cells and analysis of lymphohematopoietic potential [J].

Vodyanik, MA ;

Bork, JA ;

Thomson, JA ;

Slukvin, II .

BLOOD, 2005, 105 (02) :617-626

[59] Pluripotency and nuclear reprogramming [J].

Yamanaka, Shinya .

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 2008, 363 (1500) :2079-2087

[60] PREFERENTIAL UTILIZATION OF THE MOST JH-PROXIMAL VH GENE SEGMENTS IN PRE-B-CELL LINES [J].

YANCOPOULOS, GD ;

DESIDERIO, SV ;

PASKIND, M ;

KEARNEY, JF ;

BALTIMORE, D ;

ALT, FW .

NATURE, 1984, 311 (5988) :727-733

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