The ageing immune system: is it ever too old to become young again?

被引：303

作者：

Dorshkind, Kenneth ^{[1
]}

Montecino-Rodriguez, Encarnacion ^{[1
]}

Signer, Robert A. J. ^{[1
]}

机构：

[1] Univ Calif Los Angeles, David Geffen Sch Med, Dept Pathol & Lab Med, Los Angeles, CA 90095 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2009年 / 9卷 / 01期

基金：

美国国家卫生研究院;

关键词：

AGE-RELATED-CHANGES; BONE-MARROW; T-CELLS; CALORIC RESTRICTION; INFLUENZA VACCINES; STEM-CELLS; B-CELLS; SENESCENCE; CANCER; MICE;

D O I：

10.1038/nri2471

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Ageing is accompanied by a decline in the function of the immune system, which increases susceptibility to infections and can decrease the quality of life. The ability to rejuvenate the ageing immune system would therefore be beneficial for elderly individuals and would decrease health-care costs for society. But is the immune system ever too old to become young again? We review here the promise of various approaches to rejuvenate the function of the immune system in the rapidly growing ageing population.

引用

页码：57 / 62

页数：6

共 61 条

[1] Biology of dendritic cells in aging [J].

Agrawal, Anshu ;

Agrawal, Sudhanshu ;

Tay, Jia ;

Gupta, Sudhir .

JOURNAL OF CLINICAL IMMUNOLOGY, 2008, 28 (01) :14-20

[2] Memory T cell homeostasis and senescence during aging [J].

Akbar, AN ;

Fletcher, JM .

CURRENT OPINION IN IMMUNOLOGY, 2005, 17 (05) :480-485

[3] Molecular genetics of acute lymphoblastic leukemia [J].

Armstrong, SA ;

Look, AT .

JOURNAL OF CLINICAL ONCOLOGY, 2005, 23 (26) :6306-6315

[4] Subordinate social status modulates the vulnerability to the immunological effects of social stress [J].

Avitsur, Ronit ;

Kinsey, Steven G. ;

Bidor, Kineret ;

Bailey, Michael T. ;

Padgett, David A. ;

Sheridan, John F. .

PSYCHONEUROENDOCRINOLOGY, 2007, 32 (8-10) :1097-1105

[5] Perspective: Transforming Chronic Care for Older Persons [J].

Boult, Chad ;

Christmas, Colleen ;

Durso, Samuel C. ;

Leff, Bruce ;

Boult, Lisa B. ;

Fried, Linda P. .

ACADEMIC MEDICINE, 2008, 83 (07) :627-631

[6] Breaking down cell cycle checkpoints and DNA repair during antigen receptor gene assembly [J].

Callen, E. ;

Nussenzweig, M. C. ;

Nussenzweig, A. .

ONCOGENE, 2007, 26 (56) :7759-7764

[7] Cancer and ageing: Rival demons? [J].

Campisi, J .

NATURE REVIEWS CANCER, 2003, 3 (05) :339-349

[8] SIR2: a potential target for calorie restriction mimetics [J].

Chen, Danica ;

Guarente, Leonard .

TRENDS IN MOLECULAR MEDICINE, 2007, 13 (02) :64-71

[9] Cellular senescence in cancer and aging [J].

Collado, Manuel ;

Blasco, Maria A. ;

Serrano, Manuel .

CELL, 2007, 130 (02) :223-233

[10] Impact of CMV and EBV seropositivity on CD8 T lymphocytes in an old population from West-Sicily [J].

Colonna-Romano, Giuseppina ;

Akbar, Arne N. ;

Aquino, Alessandra ;

Bulati, Matteo ;

Candore, Giuseppina ;

Lio, Domenico ;

Ammatuna, Pietro ;

Fletcher, Jean M. ;

Caruso, Calogero ;

Pawelec, Graham .

EXPERIMENTAL GERONTOLOGY, 2007, 42 (10) :995-1002

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