Many studies have been presented discussing the use of Discrete Event Simulation (DES), This paper presents an overall view on the use of simulation, as a technique to improve manufacturing competitiveness. Considering the several functions that can be identified within a manufacturing system, DES roles will be presented. The benefits of simulation will be demonstrated with two case studies developed in Portuguese industrial companies. A new application area of DES is being developed at IFS and INETI. It will be presented the possibility of using DES, integrated with traditional functions within a company, to support process planning together with manufacturing planning and control, in a simultaneous engineering environment.