Epigenetic Reprogramming in Cancer

被引：545

作者：

Suva, Mario L. ^{[1
,2
,3
,4
,5
]}

Riggi, Nicolo ^{[1
,2
,3
,4
,5
]}

Bernstein, Bradley E. ^{[1
,2
,3
,4
,5
]}

机构：

[1] Howard Hughes Med Inst, Chevy Chase, MD 20815 USA

[2] Massachusetts Gen Hosp, Dept Pathol, Boston, MA 02114 USA

[3] Massachusetts Gen Hosp, Ctr Canc Res, Boston, MA 02114 USA

[4] Harvard Univ, Sch Med, Boston, MA 02114 USA

[5] Broad Inst Harvard & MIT, Cambridge, MA 02142 USA

来源：

SCIENCE | 2013年 / 339卷 / 6127期

基金：

瑞士国家科学基金会;

关键词：

STEM-CELLS; SOMATIC MUTATIONS; SELF-RENEWAL; HISTONE H3; GENE; PLURIPOTENCY; EXPRESSION; COMPLEX; H3K27; REGULATORS;

D O I：

10.1126/science.1230184

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The demonstration of induced pluripotency and direct lineage conversion has led to remarkable insights regarding the roles of transcription factors and chromatin regulators in mediating cell state transitions. Beyond its considerable implications for regenerative medicine, this body of work is highly relevant to multiple stages of oncogenesis, from the initial cellular transformation to the hierarchical organization of established malignancies. Here, we review conceptual parallels between the respective biological phenomena, highlighting important interrelationships among transcription factors, chromatin regulators, and preexisting epigenetic states. The shared mechanisms provide insights into oncogenic transformation, tumor heterogeneity, and cancer stem cell models.

引用

页码：1567 / 1570

页数：4

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