Barium distributions in teeth reveal early-life dietary transitions in primates

被引:161
作者
Austin, Christine [1 ,2 ,3 ,4 ]
Smith, Tanya M. [5 ]
Bradman, Asa [6 ]
Hinde, Katie [5 ,7 ]
Joannes-Boyau, Renaud [8 ]
Bishop, David [9 ]
Hare, Dominic J. [9 ,10 ]
Doble, Philip [9 ]
Eskenazi, Brenda [6 ]
Arora, Manish [1 ,2 ,3 ,4 ]
机构
[1] Icahn Sch Med Mt Sinai, Dept Prevent Med, New York, NY 10029 USA
[2] Harvard Univ, Sch Publ Hlth, Boston, MA 02115 USA
[3] Westmead Hosp, Westmead Millennium Inst, Inst Dent Res, Sydney, NSW 2145, Australia
[4] Univ Sydney, Fac Dent, Sydney, NSW 2145, Australia
[5] Harvard Univ, Dept Human Evolutionary Biol, Cambridge, MA 02138 USA
[6] Univ Calif Berkeley, Sch Publ Hlth, Ctr Environm Res & Childrens Hlth, Berkeley, CA 94720 USA
[7] Calif Natl Primate Res Ctr, Davis, CA 95616 USA
[8] So Cross Univ, Lismore, NSW 2480, Australia
[9] Univ Technol Sydney, Elemental Bioimaging Facil, Sydney, NSW 2007, Australia
[10] Univ Melbourne, Florey Inst Neurosci & Mental Hlth, Parkville, Vic 3010, Australia
基金
澳大利亚国家健康与医学研究理事会; 澳大利亚研究理事会;
关键词
TRACE-ELEMENTS; ENAMEL; NEANDERTHAL; DIAGENESIS; CHEMISTRY; SPECTROMETRY; BEHAVIOR; HISTORY; GROWTH;
D O I
10.1038/nature12169
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Early-life dietary transitions reflect fundamental aspects of primate evolution and are important determinants of health in contemporary human populations(1,2). Weaning is critical to developmental and reproductive rates; early weaning can have detrimental health effects but enables shorter inter-birth intervals, which influences population growth(3). Uncovering early-life dietary history in fossils is hampered by the absence of prospectively validated biomarkers that are not modified during fossilization(4). Here we show that large dietary shifts in early life manifest as compositional variations in dental tissues. Teeth from human children and captive macaques, with prospectively recorded diet histories, demonstrate that barium (Ba) distributions accurately reflect dietary transitions from the introduction of mother's milk through the weaning process. We also document dietary transitions in a Middle Palaeolithic juvenile Neanderthal, which shows a pattern of exclusive breastfeeding for seven months, followed by seven months of supplementation. After this point, Ba levels in enamel returned to baseline prenatal levels, indicating an abrupt cessation of breastfeeding at 1.2 years of age. Integration of Ba spatial distributions and histological mapping of tooth formation enables novel studies of the evolution of human life history, dietary ontogeny in wild primates, and human health investigations through accurate reconstructions of breastfeeding history.
引用
收藏
页码:216 / +
页数:5
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