Transition-metal-free highly efficient synthesis of 2-pyridones from β-keto amides and ynals

被引：6

作者：

Chen, Zhengwang ^{[1
]}

Liu, Jiayang ^{[1
]}

Jin, Caiju ^{[1
]}

Tan, Qi ^{[1
]}

Ye, Min ^{[1
]}

机构：

[1] Gannan Normal Univ, Key Lab Organopharmaceut Chem Jiangxi Prov, Ganzhou 341000, Jiangxi, Peoples R China

来源：

TETRAHEDRON LETTERS | 2019年 / 60卷 / 18期

关键词：

Pyridone; Ynal; Annulation reaction; Enyneamide; CATALYZED N-ARYLATION; 2+2+2 CYCLOADDITION; ISOCYANATES; ALKYNES; ACCESS;

D O I：

10.1016/j.tetlet.2019.04.001

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A convenient and efficient annulation reaction was developed, affording 2-pyridones in good to excellent yields. A variety of substituted beta-keto amides and ynals were well tolerated, and especially the transformation produced water as only by-product under transition-metal-free conditions. Furthermore, the conjugated enyneamides were achieved from beta-cyano amides and ynals in high yields. (C) 2019 Elsevier Ltd. All rights reserved.

引用

页码：1265 / 1267

页数：3

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