A preliminary evaluation of a metathesis approach to bryostatins

被引：42

作者：

Ball, M ^{[1
]}

Bradshaw, BJ ^{[1
]}

Dumeunier, R ^{[1
]}

Gregson, TJ ^{[1
]}

MacCormick, S ^{[1
]}

Omori, H ^{[1
]}

Thomas, EJ ^{[1
]}

机构：

[1] Univ Manchester, Sch Chem, Manchester M13 9PL, Lancs, England

来源：

TETRAHEDRON LETTERS | 2006年 / 47卷 / 13期

基金：

英国工程与自然科学研究理事会;

关键词：

D O I：

10.1016/j.tetlet.2006.01.097

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Preliminary investigations into the synthesis of bryostatins using ring-closing metathesis to form the C(16)-C(17) double bond led to a synthesis of the bryostatin analogue 51; precursors 26 and 52, which possess the geminal dimethyl group at G 18, did not undergo the required ring-closing metathesis. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：2223 / 2227

页数：5

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