Stem cell paracrine effect and delivery strategies for spinal cord injury regeneration

被引：72

作者：

Veneruso, V. ^{[1
]}

Rossi, F. ^{[2
]}

Villella, A. ^{[1
]}

Bena, A. ^{[1
]}

Forloni, G. ^{[1
]}

Veglianese, P. ^{[1
]}

机构：

[1] Ist Ric Farmacol Mario Negri IRCCS, Dept Neurosci, Via La Masa 19, I-20156 Milan, Italy

[2] Politecn Milan, Dept Chem Mat & Chem Engn Giulio Natta, Via Mancinelli 7, I-20131 Milan, Italy

来源：

JOURNAL OF CONTROLLED RELEASE | 2019年 / 300卷

关键词：

Stem cells; Spinal cord injury; Secreted factors; Biofactors; MARROW STROMAL CELLS; NEURAL STEM/PROGENITOR CELLS; PROMOTES FUNCTIONAL RECOVERY; CENTRAL-NERVOUS-SYSTEM; DRUG-DELIVERY; RAT MODEL; AXONAL GROWTH; HYDROGEL SCAFFOLDS; SUSTAINED-RELEASE; LOCAL-DELIVERY;

D O I：

10.1016/j.jconrel.2019.02.038

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Spinal cord injury (SCI) is a complicated neuropathological condition that results in functional dysfunction and paralysis. Various treatments have been proposed including drugs, biological factors and cells administered in several ways. Stem cell therapy offers a potentially revolutionary mode to repair the damaged spinal cord after injury. Initially, stem cells were considered promising for replacing cells and tissue lost after SCI. Many studies looked at their differentiation to replace neuronal and glial cells for a better functional outcome. However, it is becoming clear that different functional improvements recognized to stem cells are due to biomolecular activities by the transplanted stem cells rather than cell replacement. This review aimed to discuss the paracrine mechanisms for tissue repair and regeneration after stem cell transplantation in SCI. It focuses on stem cell factor production, effect in tissue restoration, and novel delivery strategies to use them for SCI therapy.

引用

页码：141 / 153

页数：13

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