New Triterpenoids from the Fruits of Schisandra wilsoniana and Their Biological Activities

被引：9

作者：

Gao, Xue-Mei ^{[1
,2
]}

Li, Yun-Qi ^{[1
,2
]}

Shu, Li-Dan ^{[1
,2
]}

Shen, Yan-Qiong ^{[1
,2
]}

Yang, Li-Ying ^{[1
,2
]}

Yang, Liu-Meng ^{[4
,5
]}

Zheng Yong-Tang ^{[4
,5
]}

Sun, Han-Dong ^{[3
]}

Xiao, Wei-Lie ^{[3
]}

Hu, Qiu-Fen ^{[1
,2
]}

机构：

[1] Yunnan Univ Nationalities, Key Lab Chem Ethn Med Resources, State Ethn Affairs Commiss, Kunming 650031, Peoples R China

[2] Yunnan Univ Nationalities, Minist Educ, Kunming 650031, Peoples R China

[3] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Yunnan, Peoples R China

[4] Chinese Acad Sci, Kunming Inst Zool, Key Lab Anim Models & Human Dis Mech, Kunming 650223, Yunnan, Peoples R China

[5] Chinese Acad Sci, Kunming Inst Zool, Lab Mol Immunopharmacol, Kunming 650223, Yunnan, Peoples R China

来源：

BULLETIN OF THE KOREAN CHEMICAL SOCIETY | 2013年 / 34卷 / 03期

关键词：

Schisandra wilsoniana; Nortriterpenoid; Anti-HIV-1; activity; Cytotoxicity; HIGHLY OXYGENATED NORTRITERPENOIDS; ANTI-HIV ACTIVITY; ANTI-HIV-1; ACTIVITIES; DIBENZOCYCLOOCTADIENE LIGNANS; CHINENSIS;

D O I：

10.5012/bkcs.2013.34.3.827

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Investigation of an organic extract of the fruits Schisandra wilsoniana led to the isolation of two new highly oxygenated. nortriterpenoids, named schilancidilactones V-W (1-2). Their structures were elucidated by spectroscopic evidence. Compounds 1-2 feature a double bond between C-7 and C-8 compared with related known nortriterpenoids isolated from the genus Schisandra. Compounds 1 and 2 were tested for their anti-HIV-1 activities and cytotoxicity. The results revealed that compounds 1 and 2 showed moderate anti-HIV-1 activities with EC50 3.05 and 2.87 mu g/mL, respectively, and compound 1 showed high cytotoxicity against KB and MDA-MB-231 cell with IC50 values of 3.18 and 5.22 mu M, respectively.

引用

页码：827 / 830

页数：4

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