Emulsion-based delivery systems for curcumin: Encapsulation and interaction mechanism between debranched starch and curcumin

被引：68

作者：

Feng, Tao ^{[1
]}

Hu, Zhongshan ^{[1
]}

Wang, Ke ^{[2
]}

Zhu, Xiao ^{[3
]}

Chen, Da ^{[4
]}

Zhuang, Haining ^{[5
]}

Yao, Lingyun ^{[1
]}

Song, Shiqing ^{[1
]}

Wang, Huatian ^{[1
]}

Sun, Min ^{[1
]}

机构：

[1] Shanghai Inst Technol, Sch Perfume & Aroma Technol, 100 Hai Quan Rd, Shanghai 201418, Peoples R China

[2] Jiangnan Univ, Sch Food Sci & Technol, Wuxi 214122, Jiangsu, Peoples R China

[3] Purdue Univ, Dept Agr & Biol Engn, Informat Technol Purdue, Res Comp, W Lafayette, IN 47907 USA

[4] Ohio State Univ, Dept Food Sci & Technol, 2015 Fyffe Rd, Columbus, OH 43210 USA

[5] Shanghai Acad Agr Sci, Inst Edible Fungi, Key Lab Edible Fungi Resources & Utilizat South, Minist Agr,Natl Engn Res Ctr Edible Fungi, Shanghai 201403, Peoples R China

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2020年 / 161卷

基金：

中国国家自然科学基金;

关键词：

Debranched starch; Curcumin; Interaction mechanism; Emulsion; Molecular dynamics simulation; MOLECULAR-DYNAMICS SIMULATION; ACID COMPLEX; STABILITY; NMR; OLIGOSACCHARIDES; NANOPARTICLES; SOLUBILITY; POLYSACCHARIDE; SPECTROSCOPY; NANOEMULSION;

D O I：

10.1016/j.ijbiomac.2020.06.088

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Curcumin has been widely recognized as health-promoting compound. However, the intrinsic hydrophobicity, chemical instability and photodegradation limits its applications in foods. In this study, a novel emulsion was developed to encapsulate curcumin using debranched starch (DBS). The encapsulation efficiency of curcumin was 71.11% with a loading rate of 12.07%. The prepared emulsions showed better stability and solubility of curcumin than those stabilized only with Tween80 and lectin. The DBS incorporated emulsion had a uniform droplet size distribution with an average value of b1 mu m. The molecular dynamics (MD) simulation showed that the water bridge between debranched starch and curcumin may play an important role in the complexation process, thus contributing to a better performance of the emulsion. This work shed light on the encapsulation process and interaction between DBS and curcumin, which is valuable to develop new emulsion-based delivery systems for bioactive lipophilic compounds using modified starch. (c) 2020 Elsevier B.V. All rights reserved.

引用

页码：746 / 754

页数：9

共 51 条

[1] Process optimization of ultrasound-assisted curcumin nanoemulsions stabilized by OSA-modified starch [J].

Abbas, Shabbar ;

Bashari, Mohanad ;

Akhtar, Waseem ;

Li, Wei Wei ;

Zhang, Xiaoming .

ULTRASONICS SONOCHEMISTRY, 2014, 21 (04) :1265-1274

[2] Development of native and modified banana starch nanoparticles as vehicles for curcumin [J].

Acevedo-Guevara, Leonardo ;

Nieto-Suaza, Leonardo ;

Sanchez, Leidy T. ;

Pinzon, Magda I. ;

Villa, Cristian C. .

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2018, 111 :498-504

[3] Fabrication of amorphous curcumin nanosuspensions using β-lactoglobulin to enhance solubility, stability, and bioavailability [J].

Aditya, N. P. ;

Yang, Hanjoo ;

Kim, Saehoon ;

Ko, Sanghoon .

COLLOIDS AND SURFACES B-BIOINTERFACES, 2015, 127 :114-121

[4] Curcuminoids-loaded liposomes in combination with arteether protects against Plasmodium berghei infection in mice [J].

Aditya, N. P. ;

Chimote, Geetanjali ;

Gunalan, Karthigayan ;

Banerjee, Rinti ;

Patankar, Swati ;

Madhusudhan, Basavaraj .

EXPERIMENTAL PARASITOLOGY, 2012, 131 (03) :292-299

[5] Nanoemulsion- and emulsion-based delivery systems for curcumin: Encapsulation and release properties [J].

Ahmed, Kashif ;

Li, Yan ;

McClements, David Julian ;

Xiao, Hang .

FOOD CHEMISTRY, 2012, 132 (02) :799-807

[6] Predicting the molecular shape of polysaccharides from dynamic interactions with water [J].

Almond, A ;

Sheehan, JK .

GLYCOBIOLOGY, 2003, 13 (04) :255-264

[7] Recent advances in emulsion-based delivery approaches for curcumin: From encapsulation to bioaccessibility [J].

Araiza-Calahorra, Andrea ;

Akhtar, Mahmood ;

Sarkar, Anwesha .

TRENDS IN FOOD SCIENCE & TECHNOLOGY, 2018, 71 :155-169

[8] Effects of enzymatic modifications and botanical source on starch-stearic acid complex formation [J].

Arijaje, Emily Oluwaseun ;

Wang, Ya-Jane .

STARCH-STARKE, 2016, 68 (7-8) :700-708

[9] Toxicity prediction of compounds from turmeric (Curcuma longa L.) [J].

Balaji, S. ;

Chempakam, B. .

FOOD AND CHEMICAL TOXICOLOGY, 2010, 48 (10) :2951-2959

[10] Modeling the α(1→6) branch point of amylopectin in solution [J].

Best, RB ;

Jackson, GE ;

Naidoo, KJ .

JOURNAL OF PHYSICAL CHEMISTRY B, 2002, 106 (19) :5091-5098

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