Synthesis of Nucleo Aminooxy Acid Derivatives

被引：10

作者：

Noel, Olivier ^{[1
]}

Xie, Juan ^{[1
]}

机构：

[1] ENS Cachan, PPSM, Inst Alembert, CNRS,UMR 8531, F-94235 Cachan, France

来源：

SYNTHESIS-STUTTGART | 2013年 / 45卷 / 01期

关键词：

nucleo aminooxy acids; nucleopeptides; N-oxy nucleopeptides; cytosine; thymine; amides; triazoles; L-serine; eliminations; PEPTIDE; DESIGN; INHIBITION; MONOMERS; HELICES; PNAS;

D O I：

10.1055/s-0032-1317689

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Nucleobase-functionalized peptides have attracted increasing interest because of their well-ordered secondary structures and stability toward enzymatic degradations. We have designed and synthesized nucleo aminooxy acids as novel building blocks for nucleopeptides. Four nucleo aminooxy acid derivatives with cytosine or thymine in the side chain linked by an amide or a triazole moiety have been synthesized from L-serine.

引用

页码：134 / 140

页数：7

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