Structure and Charge-State Dependence of the Gas-Phase Ionization Energy of Proteins

被引：30
|
作者：
Giuliani, Alexandre [1 ,2 ]
Milosavljevic, Aleksandar R. [5 ]
Hinsen, Konrad [4 ]
Canon, Francis [1 ,3 ]
Nicolas, Christophe [1 ]
Refregiers, Matthieu [1 ]
Nahon, Laurent [1 ]
机构：
[1] Synchrotron SOLEIL, F-91192 Gif Sur Yvette, France
[2] INRA, CEPIA, UAR1008, F-44316 Nantes, France
[3] INRA, Ctr Sci Gout & Alimentat, UMR1324, F-21034 Dijon, France
[4] CNRS, Ctr Biophys Mol, UPR4301, F-45071 Orleans, France
[5] Univ Belgrade, Inst Phys, Belgrade 11001, Serbia
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2012年 / 51卷 / 38期
关键词：
ionization potentials; mass spectrometry; protein structures; X-RAY-SCATTERING; CYTOCHROME-C; IN-VACUO; FOLDING MECHANISMS; MASS-SPECTROMETRY; SPECTROSCOPY; IONS; PRINCIPLES; TRAP;
D O I：
10.1002/anie.201204435
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Photoionization of protein ions: The ionization energy of polyprotonated protein cations in the gas phase measured using VUV synchrotron radiation appears to be correlated with the charge state z of the protein and its tertiary structure. A simple electrostatic model accounts for the results and also shows predictive capabilities to derive a mean radius Rm of the protein ion from the ionization energy, and vice versa. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：9552 / 9556
页数：5
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