Resiliency of Lung Cancers to EGFR Inhibitor Treatment Unveiled, Offering Opportunities to Divide and Conquer EGFR Inhibitor Resistance

被引：32

作者：

Blakely, Collin M. ^{[1
]}

Bivona, Trever G. ^{[1
]}

机构：

[1] Univ Calif San Francisco, Dept Med, Div Hematol & Oncol, Helen Diller Comprehens Canc Ctr, San Francisco, CA 94158 USA

来源：

CANCER DISCOVERY | 2012年 / 2卷 / 10期

关键词：

TARGETED THERAPY; CHEMOTHERAPY; ERLOTINIB;

D O I：

10.1158/2159-8290.CD-12-0387

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The clinical success of EGF receptor (EGFR) inhibitors in patients with lung cancer is limited by the inevitable development of treatment resistance. Two reports in this issue of Cancer Discovery uncover additional mechanisms by which EGFR-mutant lung cancers escape from EGFR kinase inhibitor treatment. These findings pave the way for clinical testing of new rational therapeutic strategies to prevent or overcome resistance to EGFR kinase inhibitors in the clinic. Cancer Discov; 2(10);872-5. (C) 2012 AACR.

引用

页码：872 / 875

页数：4

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