(-)-Epigallocatechin-3-O-gallate (EGCG) attenuates the hemodynamics stimulated by caffeine through decrease of catecholamines release

被引:6
作者
Han, Jin-Yi [1 ]
Moon, Yong-Jin [2 ]
Han, Jong-Hyun [2 ]
Kim, Jong-Hoon [3 ]
Woo, Jae-Hoon [4 ,5 ]
Yoo, Hwan-Soo [4 ,5 ]
Hong, Jin Tae [4 ,5 ]
Ahn, Hee-Yul [6 ]
Hong, Jong-Myeon [6 ]
Oh, Ki-Wan [4 ,5 ]
机构
[1] Chungbuk Natl Univ, Coll Vet Med, Cheongju 362763, South Korea
[2] Wonkwang Univ, Coll Oriental Med, Iksan 579749, South Korea
[3] Chonbuk Natl Univ, Coll Vet Med, Jeonju 579749, South Korea
[4] Chungbuk Natl Univ, Coll Pharm, Cheongju 28644, South Korea
[5] Chungbuk Natl Univ, Med Res Ctr, Cheongju 28644, South Korea
[6] Chungbuk Natl Univ, Coll Med, Cheongju 28644, South Korea
基金
新加坡国家研究基金会;
关键词
Epigallocatechin-3-O-gallate (EGCG); Caffeine; Hemodynamics; Catecholamines; Counteraction; Blood pressure; Heart rate; BLOOD-PRESSURE; GREEN; GALLATE; CATECHINS; RESPONSES; EXTRACT; CHANNEL; SYSTEM; L;
D O I
10.1007/s12272-016-0757-1
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
A human study of the effects on hemodynamics of caffeine and epigallocatechin-3-O-gallate (EGCG) was performed. Caffeine tablets (200 mg) were orally administered to healthy males aged between 25 and 35 years 30 min after oral administration of EGCG tablets (100 and 200 mg). The increase in BP induced by caffeine was inhibited when co-administrated with EGCG. We found that caffeine slightly decreased heart rate (HR) in the volunteers. Although EGCG enhanced HR reduction, the effect was not significant. In addition, caffeine increased blood catecholamine levels, but EGCG inhibited the increase in noradrenaline, adrenaline and dopamine levels induced by caffeine. Whether EGCG decreases the elevated HR and systolic perfusion pressure, and ventricular contractility induced by adrenergic agonists in the isolated rat heart was investigated. The modified Krebs-Henseleit solution was perfused through a Langendorff apparatus to the isolated hearts of rats. HR, systolic perfusion pressure, and developed maximal rates of contraction (+dP/dt(max)) and relaxation (-dP/dt(max)) were increased by epinephrine (EP) and isoproterenol (IP). In contrast, EGCG decreased the elevated HR, systolic perfusion pressure, and left ventricular +/- dp/dt(max) induced by EP and/or IP. In conclusion, EGCG could attenuate the hemodynamics stimulated by caffeine through decreasing catecholamine release.
引用
收藏
页码:1307 / 1312
页数:6
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