Common variants of FUT2 are associated with plasma vitamin B12 levels

被引：125

作者：

Hazra, Aditi ^{[1
,2
,3
]}

Kraft, Peter ^{[1
]}

Selhub, Jacob ^{[4
]}

Giovannucci, Edward L. ^{[2
,3
,5
]}

Thomas, Gilles ^{[6
]}

Hoover, Robert N. ^{[6
]}

Chanock, Stephen J. ^{[6
]}

Hunter, David J. ^{[1
,2
,3
,5
,6
,7
,8
]}

机构：

[1] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Program Mol & Genet Epidemiol, Boston, MA 02115 USA

[2] Brigham & Womens Hosp, Dept Med, Channing Lab, Boston, MA 02115 USA

[3] Harvard Univ, Sch Med, Boston, MA 02115 USA

[4] Tufts Univ, Jean Mayer US Dept Agr, Human Nutr Res Ctr Aging, Vitamin Metab & Aging Lab, Boston, MA 02111 USA

[5] Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA

[6] NCI, Div Canc Epidemiol & Genet, NIH, DHHS, Bethesda, MD 20892 USA

[7] MIT, Broad Inst, Program Med & Populat Genet, Cambridge, MA 02142 USA

[8] Harvard Univ, Cambridge, MA 02142 USA

来源：

NATURE GENETICS | 2008年 / 40卷 / 10期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/ng.210

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We identified a strong association (P = 5.36 x 10(-17)) between rs492602 in FUT2 and plasma vitamin B-12 levels in a genome-wide scan (n = 1,658) and an independent replication sample (n = 1,059) from the Nurses' Health Study. Women homozygous for the rs492602[G] allele had higher B12 levels. This allele is in strong linkage disequilibrium with the FUT2 nonsecretor variant encoding W143X, suggesting a plausible mechanism for altered B12 absorption and plasma levels.

引用

页码：1160 / 1162

页数：3

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