An endoplasmic reticulum-targetable fluorescent probe for highly selective detection of hydrogen sulfide

被引：50

作者：

Zhang, Hui ^{[1
,2
]}

Chen, Jiali ^{[2
]}

Xiong, Haiqing ^{[1
]}

Zhang, Yun ^{[1
]}

Chen, Wenqiang ^{[2
]}

Sheng, Jiarong ^{[2
]}

Song, Xiangzhi ^{[1
,3
]}

机构：

[1] Cent S Univ, Coll Chem & Chem Engn, Changsha 410083, Hunan, Peoples R China

[2] Nanning Normal Univ, Coll Chem & Mat Sci, Guangxi Key Lab Nat Polymer Chem & Phys, Nanning 530001, Peoples R China

[3] Key Lab Hunan Prov Water Environm & Agr Product S, Changsha 410083, Hunan, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2019年 / 17卷 / 06期

关键词：

H2S; VISUALIZATION; MITOCHONDRIA; COUMARINS; SYNERGY; SULFUR; CELLS;

D O I：

10.1039/c8ob02998a

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Hydrogen sulfide (H2S), a critical endogenous signaling molecule, is widely involved in many physiological processes. Endoplasmic reticulum, an important organelle with a sac-like structure, plays crucial roles in maintaining the normal function of cells. Accordingly, monitoring the H2S levels in endoplasmic reticulum is of great importance. Herein, we have developed an endoplasmic reticulum-targetable fluorescent probe, ER-CN, for H2S detection. ER-CN features excellent sensing properties, such as high sensitivity and selectivity. In addition, ER-CN exhibits low cytotoxicity and a fine endoplasmic reticulum targeting property (with a Pearson's colocalization coefficient of 0.95). Significantly, visualization of H2S in the endoplasmic reticulum of living HeLa cells by using ER-CN was successfully realized.

引用

页码：1436 / 1441

页数：6

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