Araliachinoside A: A New Triterpene Glycoside From Aralia chinensis Leaves

被引：3

作者：

Pham Hai Yen ^{[1
,2
]}

Nguyen Thi Cuc ^{[1
]}

Phan Thi Thanh Huong ^{[1
]}

Nguyen Xuan Nhiem ^{[1
,2
]}

Nguyen Thi Hoai ^{[3
]}

Ho Duc Viet ^{[3
]}

Bui Huu Tai ^{[1
,2
]}

Nguyen Van Tuyen ^{[4
]}

Chau Van Minh ^{[1
]}

Phan Van Kiem ^{[1
,2
]}

机构：

[1] Vietnam Acad Sci & Technol VAST, Inst Marine Biochem, Hanoi, Vietnam

[2] Grad Univ Sci & Technol, Vietnam Acad Sci & Technol VAST, Hanoi, Vietnam

[3] Hue Univ, Hue Univ Med & Pharm, Fac Pharm, Hue City, Vietnam

[4] Viemam Acad Sci & Technol VAST, Inst Chem, Hanoi, Vietnam

来源：

NATURAL PRODUCT COMMUNICATIONS | 2020年 / 15卷 / 09期

关键词：

araliaceae; Aralia chinensis; araliachinoside A; triterpene glycoside; cytotoxic activity; SAPONINS;

D O I：

10.1177/1934578X20952756

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

From the leaves of Aralia chinensis, 3 oleanane-type triterpene glycosides have been isolated, including 1 new glycoside, 3 beta,23-dihydroxyolean-12-ene-28-oic acid 3-O-beta-D-glucopyranosyl-(1 -> 3)-alpha-L-arabinopyranosyl-(1 -> 3)-beta-D-glucuronopyranoside 28-O-beta-D-glucopyranosyl ester (named as araliachinoside A, 1), and 2 known ones, 3 beta,23-dihydroxyolean-12-ene-28-oic acid 3-O-alpha-L-arabinopyranosyl-(1 -> 3)-beta-D-glucuronopyranoside 28-O-beta-D-glucopyronosyl ester (2) and 3 beta-hydroxyolean-12-ene-28-oic acid 3-O-beta-D-glucurono pyranoside 28-O-beta-D-glucopyronosyl ester (3). Their chemical structures were elucidated by using a combination of high-resolution electrospray ionization-mass spectrometry, 1-dimensional and 2-dimensional nuclear magnetic resonance spectral data, and by comparison with previous literature. Compounds 1-3 displayed cytotoxic activity toward KB and HepG2 cell lines with half-maximal inhibitory concentration values ranging from 8.1 +/- 0.1 to 15.7 +/- 0.3 mu M in in vitro assay.

引用

页数：6

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