Mesenchymal Stem Cell-Based Tumor-Targeted Gene Therapy in Gastrointestinal Cancer

被引：42

作者：

Bao, Qi ^{[1
,2
]}

Zhao, Yue ^{[1
]}

Niess, Hanno ^{[1
]}

Conrad, Claudius ^{[3
,4
]}

Schwarz, Bettina ^{[1
]}

Jauch, Karl-Walter ^{[1
]}

Huss, Ralf ^{[5
]}

Nelson, Peter J. ^{[6
,7
]}

Bruns, Christiane J. ^{[1
]}

机构：

[1] Univ Munich, Dept Surg, D-81377 Munich, Germany

[2] Zhejiang Univ, Sch Med, Affiliated Hosp 2, Dept Plast & Reconstruct Surg, Hangzhou 310003, Zhejiang, Peoples R China

[3] Harvard Univ, Sch Med, Dept Surg, Massachusetts Gen Hosp, Boston, MA 02115 USA

[4] Harvard Stem Cell Inst, Boston, MA USA

[5] Apceth GmbH & Co KG, Munich, Germany

[6] Univ Munich, Med Klin & Poliklin 4, Nephrol Zentrum, D-81377 Munich, Germany

[7] Univ Munich, Arbeitsgrp Klin Biochem, D-81377 Munich, Germany

来源：

STEM CELLS AND DEVELOPMENT | 2012年 / 21卷 / 13期

关键词：

STROMAL CELLS; IN-VITRO; HEPATOCELLULAR-CARCINOMA; TRANSGENE EXPRESSION; POTENTIAL PRECURSORS; ANTITUMOR-ACTIVITY; DELIVERY VEHICLES; TISSUE; GROWTH; DIFFERENTIATION;

D O I：

10.1089/scd.2012.0060

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Mesenchymal stem (or stromal) cells (MSCs) are nonhematopoietic progenitor cells that can be obtained from bone marrow aspirates or adipose tissue, expanded and genetically modified in vitro, and then used for cancer therapeutic strategies in vivo. Here, we review available data regarding the application of MSC-based tumor-targeted therapy in gastrointestinal cancer, provide an overview of the general history of MSC-based gene therapy in cancer research, and discuss potential problems associated with the utility of MSC-based therapy such as biosafety, immunoprivilege, transfection methods, and distribution in the host.

引用

页码：2355 / 2363

页数：9

共 85 条

[1] Use of genetically engineered bone marrow-derived mesenchymal stem cells for glioma gene therapy [J].

Amano, Shinji ;

Li, Shaoyi ;

Gu, Chunyu ;

Gao, Yun ;

Koizumi, Shinichiro ;

Yamamoto, Seiji ;

Terakawa, Susumu ;

Namba, Hiroki .

INTERNATIONAL JOURNAL OF ONCOLOGY, 2009, 35 (06) :1265-1270

[2] The Sleeping Beauty transposon system: a non-viral vector for gene therapy [J].

Aronovich, Elena L. ;

McIvor, R. Scott ;

Hackett, Perry B. .

HUMAN MOLECULAR GENETICS, 2011, 20 :R14-R20

[3] Safety and antitumor activity of recombinant soluble Apo2 ligand [J].

Ashkenazi, A ;

Pai, RC ;

Fong, S ;

Leung, S ;

Lawrence, DA ;

Masters, SA ;

Blackie, C ;

Chang, L ;

McMurtrey, AE ;

Hebert, A ;

DeForge, L ;

Koumenis, IL ;

Lewis, D ;

Harris, L ;

Bussiere, J ;

Koeppen, H ;

Shahrokh, Z ;

Schwall, RH .

JOURNAL OF CLINICAL INVESTIGATION, 1999, 104 (02) :155-162

[4] Hepatocyte differentiation of mesenchymal stem cells from human adipose tissue in vitro promotes hepatic integration in vivo [J].

Aurich, H. ;

Sgodda, M. ;

Kaltwasser, P. ;

Vetter, M. ;

Weise, A. ;

Liehr, T. ;

Brulport, M. ;

Hengstler, J. G. ;

Dollinger, M. M. ;

Fleig, W. E. ;

Christ, B. .

GUT, 2009, 58 (04) :570-581

[5] Autologous mesenchymal stem cell transplantation in stroke patients [J].

Bang, OY ;

Lee, JS ;

Lee, PH ;

Lee, G .

ANNALS OF NEUROLOGY, 2005, 57 (06) :874-882

[6] VEGF expression by mesenchymal stem cells contributes to angiogenesis in pancreatic carcinoma [J].

Beckermann, B. M. ;

Kallifatidis, G. ;

Groth, A. ;

Frommhold, D. ;

Apel, A. ;

Mattern, J. ;

Salnikov, A. V. ;

Moldenhauer, G. ;

Wagner, W. ;

Diehlmann, A. ;

Saffrich, R. ;

Schubert, M. ;

Ho, A. D. ;

Giese, N. ;

Buechler, M. W. ;

Friess, H. ;

Buechler, P. ;

Herr, I. .

BRITISH JOURNAL OF CANCER, 2008, 99 (04) :622-631

[7]

BOCCI V, 1990, J BIOL REG HOMEOS AG, V4, P153

[8] Pharmacokinetics and pharmacodynamics of IFN-β1a in healthy volunteers [J].

Buchwalder, PA ;

Buclin, T ;

Trinchard, I ;

Munafo, A ;

Biollaz, J .

JOURNAL OF INTERFERON AND CYTOKINE RESEARCH, 2000, 20 (10) :857-866

[9] Mesenchymal Stem Cells Exhibit Firm Adhesion, Crawling, Spreading and Transmigration across Aortic Endothelial Cells: Effects of Chemokines and Shear [J].

Chamberlain, Giselle ;

Smith, Helen ;

Rainger, G. Ed ;

Middleton, Jim .

PLOS ONE, 2011, 6 (09)

[10] Prophylaxis against carcinogenesis in three kinds of unestablished tumor models via IL12-gene-engineered MSCs [J].

Chen, Xian-cheng ;

Wang, Rui ;

Zhao, Xia ;

Wei, Yu-quan ;

Hu, Min ;

Wang, Yang-sheng ;

Zhang, Xiao-wei ;

Zhang, Ru ;

Zhang, Lin ;

Yao, Bin ;

Wang, Lian ;

Jia, Yong-qian ;

Zeng, Ting-ting ;

Yang, Jin-liang ;

Kan, Bing ;

Lin, Xiao-juan ;

Lei, Song ;

Deng, Hong-xin ;

Wen, Yan-jun ;

Mao, Yong-qiu ;

Li, Jiong .

CARCINOGENESIS, 2006, 27 (12) :2434-2441

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