Synthesis and structure of a macrocyclic dinuclear Zn(II) complex together with DNA-binding and kinetic studies

被引：18
作者：
Chen, Yun-Feng [1 ]
Liu, Ming [1 ]
Mao, Jia-Wei [1 ,2 ]
Song, Hui-Ting [1 ]
Zhou, Hong [1 ]
Pan, Zhi-Quan [1 ]
机构：
[1] Wuhan Inst Technol, Minist Educ, Key Lab Green Chem Proc, Wuhan 430073, Peoples R China
[2] Wuhan Univ, Coll Chem & Mol Sci, Wuhan 430072, Peoples R China
来源：
JOURNAL OF COORDINATION CHEMISTRY | 2012年 / 65卷 / 19期
基金：
中国国家自然科学基金;
关键词：
Dinuclear Zn(II) complex; Crystal structure; DNA-binding constant; Catalytic activities; COPPER(II) COMPLEXES; PHOSPHATE DIESTER; CRYSTAL-STRUCTURE; CLEAVAGE; HYDROLYSIS; ZINC(II); MODEL; MONO; LIGANDS;
D O I：
10.1080/00958972.2012.717690
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
A new macrocyclic dinuclear Zn(II) complex, [Zn-2(OAc)L]center dot ClO4 (H2L was obtained by condensation between 3,3'-(ethane-1,2-diylbis(benzylazanediyl))bis(methylene)bis(2-hydroxy-5-methylbenzaldehyde) and aniline (1 : 2 molar ratio)), was synthesized and characterized by spectroscopy, elemental analysis, and single-crystal X-ray diffraction. The interactions of the complex with DNA have been measured by UV spectroscopy and viscosity experiment. The interaction of the complex with calf thymus DNA has a binding constant of 1.18 x 10(4) mol(-1) L. Phosphate hydrolysis of the complex was investigated using bis(4-nitrophenyl) phosphate as the substrate. The observed first-order rate constant is 4.23 x 10(-5) s(-1).
引用
收藏
页码：3413 / 3423
页数：11
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