Synthesis and structure of a macrocyclic dinuclear Zn(II) complex together with DNA-binding and kinetic studies

被引：18

作者：

Chen, Yun-Feng ^{[1
]}

Liu, Ming ^{[1
]}

Mao, Jia-Wei ^{[1
,2
]}

Song, Hui-Ting ^{[1
]}

Zhou, Hong ^{[1
]}

Pan, Zhi-Quan ^{[1
]}

机构：

[1] Wuhan Inst Technol, Minist Educ, Key Lab Green Chem Proc, Wuhan 430073, Peoples R China

[2] Wuhan Univ, Coll Chem & Mol Sci, Wuhan 430072, Peoples R China

来源：

JOURNAL OF COORDINATION CHEMISTRY | 2012年 / 65卷 / 19期

基金：

中国国家自然科学基金;

关键词：

Dinuclear Zn(II) complex; Crystal structure; DNA-binding constant; Catalytic activities; COPPER(II) COMPLEXES; PHOSPHATE DIESTER; CRYSTAL-STRUCTURE; CLEAVAGE; HYDROLYSIS; ZINC(II); MODEL; MONO; LIGANDS;

D O I：

10.1080/00958972.2012.717690

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A new macrocyclic dinuclear Zn(II) complex, [Zn-2(OAc)L]center dot ClO4 (H2L was obtained by condensation between 3,3'-(ethane-1,2-diylbis(benzylazanediyl))bis(methylene)bis(2-hydroxy-5-methylbenzaldehyde) and aniline (1 : 2 molar ratio)), was synthesized and characterized by spectroscopy, elemental analysis, and single-crystal X-ray diffraction. The interactions of the complex with DNA have been measured by UV spectroscopy and viscosity experiment. The interaction of the complex with calf thymus DNA has a binding constant of 1.18 x 10(4) mol(-1) L. Phosphate hydrolysis of the complex was investigated using bis(4-nitrophenyl) phosphate as the substrate. The observed first-order rate constant is 4.23 x 10(-5) s(-1).

引用

页码：3413 / 3423

页数：11

共 40 条

[1] Synthesis of mono and binuclear copper(II) complexes using new macrobicyclic tricompartmental unsymmetrical ligands: magnetic, electrochemical and catalytic studies [J].

Akilan, P ;

Thirumavalavan, M ;

Kandaswamy, M .

POLYHEDRON, 2003, 22 (27) :3483-3492

[2] Structural, magnetic, electrochemical, catalytic, DNA binding and cleavage studies of new macrocyclic binuclear copper(II) complexes [J].

Anbu, S. ;

Kandaswamy, M. ;

Suthakaran, P. ;

Murugan, V. ;

Varghese, Babu .

JOURNAL OF INORGANIC BIOCHEMISTRY, 2009, 103 (03) :401-410

[3]

Aubu S., 2012, INORG CHEM, V51, P5580

[4] Correlation of structure and function in oligonuclear zinc(II) model phosphatases [J].

Bauer-Siebenlist, B ;

Meyer, F ;

Farkas, E ;

Vidovic, D ;

Cuesta-Seijo, JA ;

Herbst-Irmer, R ;

Pritzkow, H .

INORGANIC CHEMISTRY, 2004, 43 (14) :4189-4202

[5] Phosphate Diester and DNA Hydrolysis by a Multivalent, Nanoparticle-Based Catalyst [J].

Bonomi, Renato ;

Selvestrel, Francesco ;

Lombardo, Valentina ;

Sissi, Claudia ;

Polizzi, Stefano ;

Mancin, Fabrizio ;

Tonellato, Umberto ;

Scrimin, Paolo .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2008, 130 (47) :15744-+

[6] An asymmetric dizinc phosphodiesterase model with phenolate and carboxylate bridges [J].

Chen, JW ;

Wang, XY ;

Zhu, YG ;

Lin, J ;

Yang, XL ;

Li, YZ ;

Lu, Y ;

Guo, ZJ .

INORGANIC CHEMISTRY, 2005, 44 (10) :3422-3430

[7] Two dinuclear Schiff-base complexes: synthesis, characterization, and biological activity [J].

Chen, Yun-Feng ;

Wei, Lai ;

Bai, Jun-Lin ;

Zhou, Hong ;

Huang, Qi-Mao ;

Li, Jun-Bo ;

Pan, Zhi-Quan .

JOURNAL OF COORDINATION CHEMISTRY, 2011, 64 (07) :1153-1164

[8] Comparison of DNA binding and cleavage abilities between mono- and trinuclear copper(II) complexes of benzimidazole derivatives [J].

Chen, Zhanfen ;

Wang, Xiaoyong ;

Li, Yizhi ;

Guo, Zijian .

INORGANIC CHEMISTRY COMMUNICATIONS, 2008, 11 (11) :1392-1396

[9] Syntheses, crystal structures, and properties of two macrocyclic dinuclear Ni(II) complexes bearing 2-pyridylmethyl pendant-arms [J].

Cheng, Q. R. ;

Chen, J. Z. ;

Zhou, H. ;

Pan, Z. Q. .

JOURNAL OF COORDINATION CHEMISTRY, 2011, 64 (07) :1139-1152

[10] New tetranuclear macrocyclic complex: Crystal structure, magnetic property and DNA cleavage activity [J].

Cheng, Qingrong ;

Pan, Zhiquan ;

Zhou, Hong ;

Chen, Jingzhong .

INORGANIC CHEMISTRY COMMUNICATIONS, 2011, 14 (06) :929-933

← 1 2 3 4 →