Ophiobolins from the Mangrove Fungus Aspergillus ustus

被引：54

作者：

Zhu, Tonghan ^{[1
]}

Lu, Zhenyu ^{[1
]}

Fan, Jie ^{[1
]}

Wang, Liping ^{[1
,2
,3
]}

Zhu, Guoliang ^{[1
]}

Wang, Yi ^{[1
]}

Li, Xia ^{[5
]}

Hong, Kui ^{[4
]}

Piyachaturawat, Pawinee ^{[6
]}

Chairoungdua, Arthit ^{[6
]}

Zhu, Weiming ^{[1
]}

机构：

[1] Ocean Univ China, Sch Med & Pharm, Minist Educ China, Key Lab Marine Drugs, Qingdao 266003, Peoples R China

[2] Key Lab Chem Nat Prod Guizhou Prov, Guiyang 550002, Peoples R China

[3] Chinese Acad Sci, Guiyang 550002, Peoples R China

[4] Wuhan Univ, Sch Pharmaceut Sci, Minist Educ China, Key Lab Combinatorial Biosynth & Drug Discovery, Wuhan 430071, Peoples R China

[5] Shandong Univ, Sch Ocean, Weihai 264209, Peoples R China

[6] Mahidol Univ, Fac Sci, Dept Physiol, Bangkok 10400, Thailand

来源：

JOURNAL OF NATURAL PRODUCTS | 2018年 / 81卷 / 01期

关键词：

MARINE NATURAL-PRODUCTS; CYTOTOXIC SESTERTERPENES; DRECHSLERA-GIGANTEA; METABOLITES; INHIBITORS; CONSTITUTION; COCHLIOBOLIN; ANALOGS; ORYZAE; ORIGIN;

D O I：

10.1021/acs.jnatprod.7b00335

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Seven new ophiobolins (1-5, 12, and 14) along with the 11 known analogues (6-11, 13, 15-18) were isolated from the ethyl acetate extracts of the liquid and solid cultures of the mangrove fungus Aspergillus ustus 094102. The structures including the absolute configurations of the seven new compounds were elucidated by spectroscopic analysis, chemical methods, and quantum ECD calculations. Compounds 4-8 and 11-15 showed cytotoxicities against the G3K, MCF-7, MD-MBA-231, MCF/Adr, A549, and HL-60 human cancer cell lines with the IC50 values ranging from 0.6 to 9.5 mu M.

引用

页码：2 / 9

页数：8

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