The effect of deacetylated gellan gum on aesculin distribution in the posterior segment of the eye after topical administration

被引：11

作者：

Chen, Qiuhong ^{[1
]}

Zheng, Yu ^{[2
]}

Li, Ye ^{[3
]}

Zeng, Ying ^{[1
]}

Kuang, JianChao ^{[1
]}

Hou, Shixiang ^{[2
]}

Li, Xiaohui ^{[4
]}

机构：

[1] Chengdu Univ Technol, Coll Mat & Chem & Chem Engn, Chengdu, Peoples R China

[2] Sichuan Univ, W China Hosp, State Key Lab Biotherapy, Chengdu 610064, Peoples R China

[3] Shanxi Acad Tradit Chinese Med, Xian, Peoples R China

[4] Third Mil Univ, Dept Med Educ, Chongqing, Peoples R China

来源：

DRUG DELIVERY | 2012年 / 19卷 / 04期

关键词：

In situ gel; corneal penetration; accumulation in posterior segment of eye; choroid-retina; pharmacokinetics; DRUG-DELIVERY; CORNEAL HYDRATION; IN-VITRO; PHARMACOKINETICS; IONTOPHORESIS; TRANSCORNEAL; PENETRATION; GELRITE; SYSTEM; HPLC;

D O I：

10.3109/10717544.2012.690003

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The aim of the present work was to evaluate the effect of deacetylated gellan gum on delivering hydrophilic drug to the posterior segment of the eye. An aesculin-containing in situ gel based on deacetylated gellan gum (AG) was prepared and characterized. In vitro corneal permeation across isolated rabbit cornea of aesculin between AG and aesculin solution (AS) was compared. The results showed that deacetylated gellan gum promotes corneal penetration of aesculin. Pharmacokinetics and ocular tissue distribution of aesculin after topical administration in rabbit eye showed that AG greatly improved aesculin accumulation in posterior segmentsrelative to AS, which was probably attributed to conjunctivital/sclera pathway. The area-under-the-curve (AUC) for AG in aqueous humor, choroid-retina, sclera and iris-ciliary body were significantly larger than those of AS. AG can be used as a potential carrier for broading the application of aesculin.

引用

页码：194 / 201

页数：8

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