Zinc is required in pyrrolidine dithiocarbamate inhibition of NF-κB activation

被引：75

作者：

Kim, CH

Kim, JH

Hsu, CY

Ahn, YS ^{[1
]}

机构：

[1] Yonsei Univ, Coll Med, Yonsei Brain Res Inst, Seoul 120752, South Korea

[2] Yonsei Univ, Coll Med, Dept Pharmacol, Seoul 120752, South Korea

[3] Washington Univ, Sch Med, Dept Neurol, St Louis, MO 63110 USA

来源：

FEBS LETTERS | 1999年 / 449卷 / 01期

关键词：

dithiocarbamate; NF-kappa B; zinc;

D O I：

10.1016/S0014-5793(99)00390-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Pyrrolidine dithiocarbamate (PDTC) is a potent inhibitor of nuclear factor kappa B (NF-kappa B) activation. PDTC inhibited basal IVF-kappa B activity of endothelial cells. PDTC, however, failed to inhibit basal NF-kappa B activity after,withdrawal of serum in the media, and the inhibitory effect of PDTC could be restored by addition of tint. When various preparations of metal ion-EDTA were tested,vith PDTC in serum-containing media, only Zn-EDTA failed to block the inhibitory effect of PDTC, The dependence on zinc was also noted in PDTC inhibition of NF-kappa B stimulated by TNF alpha. These facts suggest that zinc is required for PDTC inhibition of NF-kappa B activation. (C) 1999 Federation of European Biochemical Societies.

引用

页码：28 / 32

页数：5

共 32 条

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