Synthesis of Enantioenriched α,α-Difluoro-β-arylbutanoic Esters by Pd-Catalyzed Asymmetric Hydrogenation

被引：10

作者：

Feng, Sitian ^{[1
,2
]}

Tang, Yitian ^{[1
,2
]}

Yang, Chenjue ^{[1
,2
]}

Shen, Chaoren ^{[1
,2
]}

Dong, Kaiwu ^{[1
,2
]}

机构：

[1] East China Normal Univ, Chang Kung Chuang Inst, Sch Chem & Mol Engn, Shanghai 200062, Peoples R China

[2] East China Normal Univ, Shanghai Key Lab Green Chem & Chem Proc, Sch Chem & Mol Engn, Shanghai 200062, Peoples R China

来源：

ORGANIC LETTERS | 2020年 / 22卷 / 19期

关键词：

ENANTIOSELECTIVE SYNTHESIS; ACID; FLUORINE; CONSTRUCTION; DI; DIFLUOROMETHYLATION; CENTERS; ALKENES; IMINES; ACCESS;

D O I：

10.1021/acs.orglett.0c02700

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Synthesis of optically active gem-difluorinated organic molecules attracts a great deal of interest due to their unique properties in pharmaceutical and agrochemical areas. Herein, a series of enantioenriched alpha,alpha-difluoro-beta-arylbutanoic esters were prepared in high yields (83-99%) with moderate to excellent enantioselectivities (<= 97:3 er) by palladium-catalyzed asymmetric hydrogenation.

引用

收藏

页码：7508 / 7512

页数：5

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