Myelin proteolipid protein: An effective autoantigen and target of autoimmunity in multiple sclerosis

被引：34
作者：
Greer, Judith M. [1 ]
Pender, Michael P. [1 ]
机构：
[1] Univ Queensland, Sch Med, Neuroimmunol Res Unit, Brisbane, Qld 4072, Australia
来源：
JOURNAL OF AUTOIMMUNITY | 2008年 / 31卷 / 03期
关键词：
Antibody; Autoimmunity; Central nervous system; Demyelination; Inflammation; Multiple sclerosis; Myelin proteolipid protein; Post-translational modification; T cell;
D O I：
10.1016/j.jaut.2008.04.018
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Myelin proteolipid protein (PLP) is the most abundant protein in central nervous system (CNS) myelin and plays a major role in maintaining the structural and functional integrity of myelin. Its abundance in, and restriction to, CNS myelin and its post-translational modification by acylation make PLIP an effective autoantigen, which can induce experimental autoimmune encephalomyelitis in rodents and non-human primates and which is a target of pathogenic autoimmunity in people with multiple sclerosis, a chronic inflammatory demyelinating CNS disease. (C) 2008 Elsevier Ltd. All rights reserved.
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收藏
页码：281 / 287
页数：7
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