Evaluation of the inhibition of other metalloproteinases by matrix metalloproteinase inhibitors

被引：7

作者：

Marcotte, PA ^{[1
]}

Elmore, IN ^{[1
]}

Guan, ZW ^{[1
]}

Magoc, TJ ^{[1
]}

Albert, DH ^{[1
]}

Morgan, DW ^{[1
]}

Curtin, ML ^{[1
]}

Garland, RB ^{[1
]}

Guo, Y ^{[1
]}

Heyman, HR ^{[1
]}

Holms, JH ^{[1
]}

Sheppard, GS ^{[1
]}

Steinman, DH ^{[1
]}

Wada, CK ^{[1
]}

Davidsen, SK ^{[1
]}

机构：

[1] Abbott Labs, Div Pharmaceut Discovery, Canc Res, Abbott Pk, IL 60064 USA

来源：

JOURNAL OF ENZYME INHIBITION | 1999年 / 14卷 / 06期

关键词：

matrix metalloproteinases; MMPs; hydroxamic acid inhibitors;

D O I：

10.3109/14756369909030333

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Two series of compounds synthesized as specific matrix metalloproteinase (MMP) inhibitors have been evaluated for their inhibition of non-MMPs. In a series of substituted succinyl hydroxamic acids, some were found to be significant (IC50 < 1 mu M) inhibitors of leucine (microsomal) aminopeptidase. neprilysin (3.4.24.11), and thermolysin. Macrocyclic compounds in which the alpha carbon of the succinyl hydroxamate is linked to the side chain of the P2' amino acid were found to be good inhibitors of aminopeptidase, but not of neprilysin or thermolysin. Compounds of neither series were found to be significant inhibitors of angiotensin converting enzyme or carboxypeptidase A.

引用

页码：425 / 435

页数：11

共 39 条

[11] SUPPRESSION OF EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS IN THE LEWIS RAT BY THE MATRIX METALLOPROTEINASE INHIBITOR RO31-9790 [J].

HEWSON, AK ;

SMITH, T ;

LEONARD, JP ;

CUZNER, ML .

INFLAMMATION RESEARCH, 1995, 44 (08) :345-349

[12] CONTINUOUS SPECTROPHOTOMETRIC ASSAY FOR ANGIOTENSIN CONVERTING ENZYME [J].

HOLMQUIST, B ;

BUNNING, P ;

RIORDAN, JF .

ANALYTICAL BIOCHEMISTRY, 1979, 95 (02) :540-548

[13]

IWAHASHI M, 1994, ANTICANCER RES, V14, P1557

[14] PH-DEPENDENT AND TIME-DEPENDENT INHIBITION OF RAT-KIDNEY NEUTRAL ENDOPROTEASE 24.11 BY THIORPHAN AND PHOSPHORAMIDON [J].

JENG, AY ;

ANSELL, J ;

ERION, MD .

LIFE SCIENCES, 1989, 45 (22) :2109-2114

[15] Matrix metalloproteinases [J].

Johnson, LL ;

Dyer, R ;

Hupe, DJ .

CURRENT OPINION IN CHEMICAL BIOLOGY, 1998, 2 (04) :466-471

[16] Effects of renal neutral endopeptidase inhibition on sodium excretion, renal hemodynamics and neurohormonal activation in patients with congestive heart failure [J].

Kimmelstiel, CD ;

Perrone, R ;

Kilcoyne, L ;

Souhrada, J ;

Udelson, J ;

Smith, J ;

deBold, A ;

Griffith, J ;

Konstam, MA .

CARDIOLOGY, 1996, 87 (01) :46-53

[17] BINDING BETWEEN THERMOLYSIN AND ITS SPECIFIC INHIBITOR, PHOSPHORAMIDON [J].

KITAGISHI, K ;

HIROMI, K .

JOURNAL OF BIOCHEMISTRY, 1984, 95 (02) :529-534

[18] Ro 32-3555, an orally active collagenase inhibitor, prevents cartilage breakdown in vitro and in vivo [J].

Lewis, EJ ;

Bishop, J ;

Bottomley, KMK ;

Bradshaw, D ;

Brewster, M ;

Broadhurst, MJ ;

Brown, PA ;

Budd, JM ;

Elliott, L ;

Greenham, AK ;

Johnson, WH ;

Nixon, JS ;

Rose, F ;

Sutton, B ;

Wilson, K .

BRITISH JOURNAL OF PHARMACOLOGY, 1997, 121 (03) :540-546

[19] HUMAN MYELOID PLASMA-MEMBRANE GLYCOPROTEIN CD13 (GP150) IS IDENTICAL TO AMINOPEPTIDASE-N [J].

LOOK, AT ;

ASHMUN, RA ;

SHAPIRO, LH ;

PEIPER, SC .

JOURNAL OF CLINICAL INVESTIGATION, 1989, 83 (04) :1299-1307

[20] MOLECULAR-CLONING AND AMINO-ACID SEQUENCE OF HUMAN ENKEPHALINASE (NEUTRAL ENDOPEPTIDASE) [J].

MALFROY, B ;

KUANG, WJ ;

SEEBURG, PH ;

MASON, AJ ;

SCHOFIELD, PR .

FEBS LETTERS, 1988, 229 (01) :206-210

← 1 2 3 4 →