Treatment of obesity with the resveratrol-enriched rice DJ-526

被引：41

作者：

Baek, So-Hyeon ^{[1
]}

Chung, Hea-Jong ^{[2
]}

Lee, Heui-Kwan ^{[2
]}

D'Souza, Roshan ^{[2
]}

Jeon, Youngju ^{[2
]}

Kim, Hyeon-Jin ^{[3
]}

Kweon, Soon-Jong ^{[4
]}

Hong, Seong-Tshool ^{[2
]}

机构：

[1] Rural Dev Adm, Natl Inst Crop Sci, Iksan, Chonbuk, South Korea

[2] Chonbuk Natl Univ, Sch Med, Dept Biomed Sci, Jeonju, Chonbuk, South Korea

[3] JINIS Biopharmaceut Co, JINIS BDRD Inst, Wonju 565902, Jeollabuk Do, South Korea

[4] Rural Dev Adm, Natl Acad Agr Sci, Suwon, Gyeonggi, South Korea

来源：

SCIENTIFIC REPORTS | 2014年 / 4卷

关键词：

STILBENE SYNTHASE GENE; PROTECTS; MICE;

D O I：

10.1038/srep03879

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Obesity is the most prevalent disease in the world which poses a serious risk for various chronic diseases. However, currently there are not any therapeutic agents that reduce body weight without causing serious side effects. In order to prevent and/or treat obesity and related diseases through a nutraceutical approach, we created a resveratrol-enriched transgenic rice accumulating 1.4 mu g/g of resveratrol in its grain, DJ-526. Feeding of mice with the resveratrol-enriched rice DJ-526 showed excellent anti-obesity effect with reduction of body weights and abdominal fat volumes compared to the control by 20.0% and 31.3%, respectively. Also, the consumption of the resveratrol-enriched rice DJ526 significantly improved the blood lipid profiles and glucose levels in the animal experiments. Our resveratrol-enriched rice DJ-526 rice could provide both safe and convenient way for people with obesity and related diseases without major change of lifestyle or unwanted side effects from medication.

引用

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