A New Approach to 3-Substituted Indoles through Palladium-Catalyzed C-H Activation Followed by Intramolecular Amination Reaction of Enamines

被引:47
作者
Inamoto, Kiyofumi [1 ]
Saito, Tadataka [1 ]
Hiroya, Kou [1 ]
Doi, Takayuki [1 ]
机构
[1] Tohoku Univ, Grad Sch Pharmaceut Sci, Aoba Ku, Sendai, Miyagi 9808578, Japan
基金
日本学术振兴会;
关键词
palladium; catalysis; C-H activation; indoles; aminations;
D O I
10.1055/s-0028-1087413
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Palladium-catalyzed C-H activation followed by intramolecular amination reaction of enamine compounds was achieved using a Pd(OAc)(2) (10 mol%)/Cu(OAc)(2) (100 mol%) catalyst system in DMSO. This work introduces an entirely new approach to 3-substituted indoles.
引用
收藏
页码:3157 / 3162
页数:6
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