Impact of sar and agr on methicillin resistance in Staphylococcus aureus

被引：29

作者：

Duran, SP

Kayser, FH

BergerBachi, B

机构：

[1] UNIV ZURICH,INST MED MICROBIOL,CH-8028 ZURICH,SWITZERLAND

[2] UNIV EXTREMADURA,FAC VET MED,DEPT MED & ANIM HLTH,E-10071 CACERES,SPAIN

来源：

FEMS MICROBIOLOGY LETTERS | 1996年 / 141卷 / 2-3期

关键词：

global regulator; penicillin-binding protein; PBP1; PBP3; mecA; Staphylococcus aureus;

D O I：

10.1016/0378-1097(96)00231-5

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The global regulators agi and sai control expression of cell wall and extracellular proteins. Inactivation of either sar and/or agr in a typical heterogeneously methicillin-resistant Staphylococcus aureus resulted in a small but reproducible decrease in the number of cells in the subpopulation expressing high methicillin resistance. The amount of low affinity penicillin-binding protein PBP2', the prerequisite for methicillin resistance, was apparently not affected, however, a reduction in PBP1 and PBP3 production was observed, suggesting that these resident PBPs of the cells might be involved somehow together with PBP2' in high level methicillin resistance.

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页码：255 / 260

页数：6

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