IL-26 contributes to host defense against intracellular bacteria

被引：47

作者：

Dang, Angeline Tilly ^{[1
,2
]}

Teles, Rosane M. B. ^{[1
]}

Weiss, David I. ^{[1
,2
]}

Parvatiyar, Kislay ^{[2
]}

Sarno, Euzenir N. ^{[3
]}

Ochoa, Maria T. ^{[4
]}

Cheng, Genhong ^{[2
]}

Gilliet, Michel ^{[5
]}

Bloom, Barry R. ^{[6
]}

Modlin, Robert L. ^{[1
,2
]}

机构：

[1] Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Div Dermatol, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, David Geffen Sch Med, Dept Microbiol Immunol & Mol Genet, Los Angeles, CA 90095 USA

[3] Fundacao Oswaldo Cruz, Leprosy Lab, Rio De Janeiro, Brazil

[4] Univ Southern Calif, Sch Med, Dept Dermatol, Los Angeles, CA USA

[5] Lausanne Univ, Hosp Lausanne, Dept Med, Dermatol Serv, Lausanne, Switzerland

[6] Harvard Sch Publ Hlth, Boston, MA USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2019年 / 129卷 / 05期

关键词：

T-CELL RESPONSES; MYCOBACTERIUM-LEPRAE; ANTIMICROBIAL PEPTIDES; IMMUNE-RESPONSE; TH17; CELLS; TUBERCULOSIS; LEPROSY; GRANULYSIN; RECEPTOR-1; MUTATIONS;

D O I：

10.1172/JCI99550

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

IL-26 is an antimicrobial protein secreted by Th17 cells that has the ability to directly kill extracellular bacteria. To ascertain whether IL-26 contributes to host defense against intracellular bacteria, we studied leprosy, caused by the obligate intracellular pathogen Mycobacterium leprae, as a model. Analysis of leprosy skin lesions by gene expression profiling and immunohistology revealed that IL-26 was more strongly expressed in lesions from the self-limited tuberculoid compared with expression in progressive lepromatous patients. IL-26 directly bound to M. leprae in axenic culture and reduced bacteria viability. Furthermore, IL-26, when added to human monocyte-derived macrophages infected with M. leprae, entered the infected cell, colocalized with the bacterium, and reduced bacteria viability. In addition, IL-26 induced autophagy via the cytoplasmic DNA receptor stimulator of IFN genes (STING), as well as fusion of phagosomes containing bacilli with lysosomal compartments. Altogether, our data suggest that the Th17 cytokine IL-26 contributes to host defense against intracellular bacteria.

引用

页码：1926 / 1939

页数：14

共 66 条

[1] Estimation of serum level of interleukin-17 and interleukin-4 in leprosy, towards more understanding of leprosy immunopathogenesis [J].

Abdallah, Marwa ;

Emam, Hanaa ;

Attia, Enas ;

Hussein, Jihan ;

Mohamed, Noha .

INDIAN JOURNAL OF DERMATOLOGY VENEREOLOGY & LEPROLOGY, 2013, 79 (06) :772-776

[2] An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis [J].

Berry, Matthew P. R. ;

Graham, Christine M. ;

McNab, Finlay W. ;

Xu, Zhaohui ;

Bloch, Susannah A. A. ;

Oni, Tolu ;

Wilkinson, Katalin A. ;

Banchereau, Romain ;

Skinner, Jason ;

Wilkinson, Robert J. ;

Quinn, Charles ;

Blankenship, Derek ;

Dhawan, Ranju ;

Cush, John J. ;

Mejias, Asuncion ;

Ramilo, Octavio ;

Kon, Onn M. ;

Pascual, Virginia ;

Banchereau, Jacques ;

Chaussabel, Damien ;

O'Garra, Anne .

NATURE, 2010, 466 (7309) :973-U98

[3] Use of genetic profiling in leprosy to discriminate clinical forms of the disease [J].

Bleharski, JR ;

Li, HY ;

Meinken, C ;

Graeber, TG ;

Ochoa, MT ;

Yamamura, M ;

Burdick, A ;

Sarno, EN ;

Wagner, M ;

Röllinghoff, M ;

Rea, TH ;

Colonna, M ;

Stenger, S ;

Bloom, BR ;

Eisenberg, D ;

Modlin, RL .

SCIENCE, 2003, 301 (5639) :1527-1530

[4] Human Th17 Cells Comprise Heterogeneous Subsets Including IFN-γ-Producing Cells with Distinct Properties from the Th1 Lineage [J].

Boniface, Katia ;

Blumenschein, Wendy M. ;

Brovont-Porth, Katherine ;

McGeachy, Mandy J. ;

Basham, Beth ;

Desai, Bela ;

Pierce, Robert ;

McClanahan, Terrill K. ;

Sadekova, Svetlana ;

Malefyt, Rene de Waal .

JOURNAL OF IMMUNOLOGY, 2010, 185 (01) :679-687

[5] Interleukin-17F single-nucleotide polymorphism (7488T>C) and its association with susceptibility to leprosy [J].

Chaitanya, V. S. ;

Jadhav, R. S. ;

Lavania, M. ;

Singh, M. ;

Valluri, V. ;

Sengupta, U. .

INTERNATIONAL JOURNAL OF IMMUNOGENETICS, 2014, 41 (02) :131-137

[6] Interleukin-26 in Antibacterial Host Defense of Human Lungs Effects on Neutrophil Mobilization [J].

Che, Karlhans F. ;

Tengvall, Sara ;

Levanen, Bettina ;

Silverpil, Elin ;

Smith, Margaretha E. ;

Awad, Muhammed ;

Vikstrom, Max ;

Palmberg, Lena ;

Qvarfordt, Ingemar ;

Skold, Magnus ;

Linden, Anders .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2014, 190 (09) :1022-1031

[7] IL-26 Is Overexpressed in Rheumatoid Arthritis and Induces Proinflammatory Cytokine Production and Th17 Cell Generation [J].

Corvaisier, Murielle ;

Delneste, Yves ;

Jeanvoine, Henry ;

Preisser, Laurence ;

Blanchard, Simon ;

Garo, Erwan ;

Hoppe, Emmanuel ;

Barre, Benjamin ;

Audran, Maurice ;

Bouvard, Beatrice ;

Saint-Andre, Jean-Paul ;

Jeannin, Pascale .

PLOS BIOLOGY, 2012, 10 (09)

[8] The role of the novel Th17 cytokine IL-26 in intestinal inflammation [J].

Dambacher, J. ;

Beigel, F. ;

Zitzmann, K. ;

De Toni, E. N. ;

Goeke, B. ;

Diepolder, H. M. ;

Auernhammer, C. J. ;

Brand, S. .

GUT, 2009, 58 (09) :1207-1217

[9] Autophagy Is an Innate Mechanism Associated with Leprosy Polarization [J].

de Andrade Silva, Bruno Jorge ;

de Mattos Barbosa, Mayara Garcia ;

Andrade, Priscila Ribeiro ;

Ferreira, Helen ;

da Costa Nery, Jose Augusto ;

Corte-Real, Suzana ;

Sperandio da Silva, Gilberto Marcelo ;

Rosa, Patricia Sammarco ;

Fabri, Mario ;

Sarno, Euzenir Nunes ;

Pinheiro, Roberta Olmo .

PLOS PATHOGENS, 2017, 13 (01)

[10] Mutations in STAT3 and IL12RB1 impair the development of human IL-17-producing T cells [J].

de Beaucoudrey, Ludovic ;

Puel, Anne ;

Filipe-Santos, Orchidee ;

Cobat, Aurelie ;

Ghandil, Pegah ;

Chrabieh, Maya ;

Feinberg, Jacqueline ;

von Bernuth, Horst ;

Samarina, Arina ;

Janniere, Lucile ;

Fieschi, Claire ;

Stephan, Jean-Louis ;

Boileau, Catherine ;

Lyonnet, Stanislas ;

Jondeau, Guillaume ;

Cormier-Daire, Valerie ;

Le Merrer, Martine ;

Hoarau, Cyrille ;

Lebranchu, Yvon ;

Lortholary, Olivier ;

Chandesris, Marie-Olivia ;

Tron, Francois ;

Gambineri, Eleonora ;

Bianchi, Lucia ;

Rodriguez-Gallego, Carlos ;

Zitnik, Simona E. ;

Vasconcelos, Julia ;

Guedes, Margarida ;

Vitor, Artur Bonito ;

Marodi, Laszlo ;

Chapel, Helen ;

Reid, Brenda ;

Roifman, Chaim ;

Nadal, David ;

Reichenbach, Janine ;

Caragol, Isabel ;

Garty, Ben-Zion ;

Dogu, Figen ;

Camcioglu, Yildiz ;

Gulle, Sanyie ;

Sanal, Ozden ;

Fischer, Alain ;

Abel, Laurent ;

Stockinger, Birgitta ;

Picard, Capucine ;

Casanova, Jean-Laurent .

JOURNAL OF EXPERIMENTAL MEDICINE, 2008, 205 (07) :1543-1550

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