Imipramine-Induced c-Fos Expression in the Medial Prefrontal Cortex is Decreased in the ACTH-Treated Rats

被引：16

作者：

Li, Bingjin ^{[1
,3
]}

Suemaru, Katsuya ^{[2
,3
]}

Kitamura, Yoshihisa ^{[4
]}

Gomita, Yutaka ^{[2
]}

Araki, Hiroaki ^{[3
]}

Cui, Ranji ^{[1
,3
]}

机构：

[1] NE Normal Univ, Sch Life Sci, Changchun 130024, Peoples R China

[2] Shujitsu Univ, Sch Pharm, Okayama 7038516, Japan

[3] Ehime Univ, Sch Med, Div Hosp Pharm, Matsuyama, Ehime 7910295, Japan

[4] Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Pharmaceut Care & Hlth Sci, Okayama 7008530, Japan

来源：

JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY | 2013年 / 27卷 / 11期

关键词：

Cell; c-Fos; Depression; Medial Prefrontal cCrtex; TREATMENT-RESISTANT DEPRESSION; CENTRAL EXTENDED AMYGDALA; ANTIDEPRESSANT DRUGS; RECEPTOR-BINDING; 5-HT2A RECEPTOR; STRESS; BRAIN; MOOD; DESMETHYLIMIPRAMINE; IMMUNOREACTIVITY;

D O I：

10.1002/jbt.21510

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Previous studies have shown that the antidepressive-like effect of tricyclic antidepressants is blocked by repeated treatments with adrenocorticotropic hormone (ACTH). However, little is known about the neuroanatomy underlying the mechanism of the imipramine treatment-resistant depression model. In the present study, first experimental evidence showed no significant difference of the serum imipramine concentrations between the saline and ACTH-treated rats. In further study, imipramine produced significant increases in the c-Fos expression in the medial prefrontal cortex (mPFC), the dentate gyrus of the hippocampus (DGH), and the central nucleus of the amygdala (CeA), in rats repeatedly treated with saline. The imipramine-increased c-Fos immunoreactivity was suppressed in the mPFC of rats repeatedly treated with ACTH. However, there was no significant difference in c-Fos expression in the DGH and CeA between ACTH- and saline-treated rats. These results suggest that the mPFC is maybe involved in effects of the imipramine in the ACTH-treated rats. (c) 2013 Wiley Periodicals, Inc. J BiochemMol Toxicol 27:486-491, 2013; View this article online at wileyonlinelibrary.com. DOI 10.1002/jbt.21510

引用

页码：486 / 491

页数：6

共 35 条

[11] LACK OF EFFECT OF RAPHE LESIONS ON SEROTONIN-S2 RECEPTOR CHANGES INDUCED BY AMITRIPTYLINE AND DESMETHYLIMIPRAMINE [J].

DUMBRILLEROSS, A ;

TANG, SW ;

COSCINA, DV .

PSYCHIATRY RESEARCH, 1982, 7 (02) :145-151

[12]

GREDEN JF, 1983, ARCH GEN PSYCHIAT, V40, P493

[13] Recruitment of Prefrontal Cortical Endocannabinoid Signaling by Glucocorticoids Contributes to Termination of the Stress Response [J].

Hill, Matthew N. ;

McLaughlin, Ryan J. ;

Pan, Bin ;

Fitzgerald, Megan L. ;

Roberts, Christopher J. ;

Lee, Tiffany T-Y ;

Karatsoreos, Ilia N. ;

Mackie, Ken ;

Viau, Victor ;

Pickel, Virginia M. ;

McEwen, Bruce S. ;

Liu, Qing-song ;

Gorzalka, Boris B. ;

Hillard, Cecilia J. .

JOURNAL OF NEUROSCIENCE, 2011, 31 (29) :10506-10515

[14] HMPAO SPECT brain imaging in treatment-resistant depression [J].

Hornig, M ;

Mozley, PD ;

Amsterdam, JD .

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 1997, 21 (07) :1097-1114

[15] Withdrawal-induced c-Fos expression in the rat centromedial amygdala 24 h following a single morphine exposure [J].

Jin, CY ;

Araki, H ;

Nagata, M ;

Suemaru, K ;

Shibata, K ;

Kawasaki, H ;

Hamamura, T ;

Gomita, Y .

PSYCHOPHARMACOLOGY, 2004, 175 (04) :428-435

[16] Influence of ACTH on the effects of imipramine, desipramine and lithium on duration of immobility of rats in the forced swim test [J].

Kitamura, Y ;

Araki, H ;

Gomita, Y .

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 2002, 71 (1-2) :63-69

[17] Effects of imipramine and lithium on wet-dog shakes mediated by the 5-HT2A receptor in ACTH-treated rats [J].

Kitamura, Y ;

Araki, H ;

Suemaru, K ;

Gomita, Y .

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 2002, 72 (1-2) :397-402

[18] EFFECT OF ACTH, ADRENALECTOMY AND THE COMBINATION TREATMENT ON THE DENSITY OF 5-HT(2) RECEPTOR-BINDING SITES IN NEOCORTEX OF RAT FOREBRAIN AND 5-HT(2) RECEPTOR-MEDIATED WET-DOG SHAKE BEHAVIORS [J].

KURODA, Y ;

MIKUNI, M ;

OGAWA, T ;

TAKAHASHI, K .

PSYCHOPHARMACOLOGY, 1992, 108 (1-2) :27-32

[19]

LAFAILLE F, 1991, J PSYCHIATR NEUROSCI, V16, P209

[20] Effects of Flavonoids on Matrix Metalloproteinase-13 Expression of Interleukin-1β-Treated Articular Chondrocytes and Their Cellular Mechanisms: Inhibition of c-Fos/AP-1 and JAK/STAT Signaling Pathways [J].

Lim, Hyun ;

Park, Haeil ;

Kim, Hyun Pyo .

JOURNAL OF PHARMACOLOGICAL SCIENCES, 2011, 116 (02) :221-231

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