Neural correlates of the components of the clock drawing test

被引：19

作者：

Matsuoka, Teruyuki ^{[1
]}

Narumoto, Jin ^{[1
]}

Okamura, Aiko ^{[1
]}

Taniguchi, Shogo ^{[1
]}

Kato, Yuka ^{[1
]}

Shibata, Keisuke ^{[1
]}

Nakamura, Kaeko ^{[1
]}

Okuyama, Chio ^{[2
]}

Yamada, Kei ^{[2
]}

Fukui, Kenji ^{[1
]}

机构：

[1] Kyoto Prefectural Univ Med, Grad Sch Med Sci, Dept Psychiat, Kamigyo Ku, Kyoto 6028566, Japan

[2] Kyoto Prefectural Univ Med, Dept Radiol, Grad Sch Med Sci, Kamigyo Ku, Kyoto 6028566, Japan

来源：

INTERNATIONAL PSYCHOGERIATRICS | 2013年 / 25卷 / 08期

基金：

日本学术振兴会;

关键词：

clock drawing test; Alzheimer's disease; single photon emission computed tomography; statistical parametric mapping 8; drug-naive patients; MILD COGNITIVE IMPAIRMENT; ALZHEIMERS-DISEASE; QUALITATIVE ANALYSES; SCORING METHODS; TEST-PERFORMANCE; MEMORY; RETRIEVAL; DEMENTIA;

D O I：

10.1017/S1041610213000690

中图分类号：

B849 [应用心理学];

学科分类号：

040203 ;

摘要：

Background: The aim of this study was to identify the neural correlates of each component of the clock drawing test (CDT) in drug-naive patients with Alzheimer's disease (AD) using single photon emission computed tomography. Methods: The participants were 95 drug-naive patients with AD. The Rouleau CDT was used to score the clock drawings. The score for the Rouleau CDT (R total) is separated into three components: the scores for the clock face (R1), the numbers (R2), and the hands (R3). A multiple regression analysis was performed to examine the relationship of each score (i.e. R total, R1, R2, and R3) with regional cerebral blood flow (rCBF). Age, gender, and education were included as covariates. The statistical threshold was set to a family-wise error (FWE)-corrected p value of 0.05 at the voxel level. Results: The R total score was positively correlated with rCBF in the bilateral parietal and posterior temporal lobes and the right middle frontal gyrus. R1 was not significantly positively correlated with rCBF, R2 was significantly positively correlated with rCBF in the right posterior temporal lobe and the left posterior middle temporal lobe, and R3 was significantly positively correlated with rCBF in the bilateral parietal lobes, the right posterior temporal lobe, the right middle frontal gyrus, and the right occipital lobe. Conclusions: Various brain regions were associated with each component of the CDT. These results suggest that an assessment of these components is useful for the detection of localization of brain damage.

引用

页码：1317 / 1323

页数：7

共 32 条

[1] Quantitative and qualitative analyses of clock drawing in frontotemporal dementia and Alzheimer's disease [J].