Structure, dynamics and function of nuclear pore complexes

被引:291
作者
D'Angelo, Maximiliano A. [1 ]
Hetzer, Martin W. [1 ]
机构
[1] Salk Inst Biol Studies, Mol & Cell Biol Lab, La Jolla, CA 92037 USA
关键词
D O I
10.1016/j.tcb.2008.07.009
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Nuclear pore complexes are large aqueous channels that penetrate the nuclear envelope, thereby connecting the nuclear interior with the cytoplasm. Until recently, these macromolecular complexes were viewed as static structures, the only function of which was to control the molecular trafficking between the two compartments. It has now become evident that this simplistic scenario Is inaccurate and that nuclear pore complexes are highly dynamic multiprotein assemblies involved in diverse cellular processes ranging from the organization of the cytoskeleton to gene expression. In this review, we discuss the most recent developments in the nuclear-pore-complex field, focusing on the assembly, disassembly, maintenance and function of this macromolecular structure.
引用
收藏
页码:456 / 466
页数:11
相关论文
共 131 条
  • [21] The nuclear pore complex: disease associations and functional correlations
    Cronshaw, JM
    Matunis, MJ
    [J]. TRENDS IN ENDOCRINOLOGY AND METABOLISM, 2004, 15 (01) : 34 - 39
  • [22] The role of the nuclear envelope in cellular organization
    D'Angelo, MA
    Hetzer, MW
    [J]. CELLULAR AND MOLECULAR LIFE SCIENCES, 2006, 63 (03) : 316 - 332
  • [23] Nuclear pores form de novo from both sides of the nuclear envelope
    D'Angelo, MA
    Anderson, DJ
    Richard, E
    Hetzer, MW
    [J]. SCIENCE, 2006, 312 (5772) : 440 - 443
  • [24] Nuclear pore complexes form immobile networks and have a very low turnover in live mammalian cells
    Daigle, N
    Beaudouin, J
    Hartnell, L
    Imreh, G
    Hallberg, E
    Lippincott-Schwartz, J
    Ellenberg, J
    [J]. JOURNAL OF CELL BIOLOGY, 2001, 154 (01) : 71 - 84
  • [25] Partial nuclear pore complex disassembly during closed mitosis in Aspergillus nidulans
    De Souza, CPC
    Osmani, AH
    Hashmi, SB
    Osmani, S
    [J]. CURRENT BIOLOGY, 2004, 14 (22) : 1973 - 1984
  • [26] Disorder in the nuclear pore complex: The FG repeat regions of nucleoporins are natively unfolded
    Denning, DP
    Patel, SS
    Uversky, V
    Fink, AL
    Rexach, M
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (05) : 2450 - 2455
  • [27] High resolution analysis of mammalian nuclear structure throughout the cell cycle: implications for nuclear pore complex assembly during interphase and mitosis
    Drummond, Sheona P.
    Rutherford, Sandra A.
    Sanderson, Helen S.
    Allen, Terry D.
    [J]. CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 2006, 84 (3-4) : 423 - 430
  • [28] Systematic kinetic analysis of mitotic dis- and reassembly of the nuclear pore in living cells
    Dultz, Elisa
    Zanin, Esther
    Wurzenberger, Claudia
    Braun, Marion
    Rabut, Gwenael
    Sironi, Lucia
    Ellenberg, Jan
    [J]. JOURNAL OF CELL BIOLOGY, 2008, 180 (05) : 857 - 865
  • [29] The role of nuclear envelope calcium in modifying nuclear pore complex structure
    Erickson, Elizabeth S.
    Mooren, Olivia L.
    Moore, David
    Krogmeier, Jeffrey R.
    Dunn, Robert C.
    [J]. CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 2006, 84 (3-4) : 309 - 318
  • [30] Domain-specific antibodies reveal multiple-site topology of Nup153 within the nuclear pore complex
    Fahrenkrog, B
    Maco, B
    Fager, AM
    Köser, J
    Sauder, U
    Ullman, KS
    Aebi, U
    [J]. JOURNAL OF STRUCTURAL BIOLOGY, 2002, 140 (1-3) : 254 - 267