Functional Role of MicroRNAs in Thymocyte Development

被引：10
作者：
Hu, Lin [1 ,2 ]
Mao, Ling [1 ,2 ]
Liu, Shiming [1 ,2 ]
Zhao, Juanjuan [1 ,2 ]
Chen, Chao [1 ,2 ]
Guo, Mengmeng [1 ,2 ]
He, Zhixu [3 ]
Yang, Jie [4 ,5 ]
Xu, Wei [4 ,5 ]
Xu, Lin [1 ,2 ]
机构：
[1] Zunyi Med Univ, Special Key Lab Gene Detect & Therapy Guizhou Pro, Zunyi, Peoples R China
[2] Zunyi Med Univ, Dept Immunol, Zunyi 563003, Guizhou, Peoples R China
[3] Guizhou Med Univ, Stem Cell & Tissue Engn Res Ctr, Guiyang, Guizhou, Peoples R China
[4] Soochow Univ, Inst Biol Sci, Jiangsu Prov Key Lab Infect & Immun, Suzhou 215006, Jiangsu, Peoples R China
[5] Soochow Univ, Inst Med Sci, Jiangsu Prov Key Lab Infect & Immun, Suzhou 215006, Jiangsu, Peoples R China
来源：
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY | 2019年 / 178卷 / 04期
基金：
中国国家自然科学基金;
关键词：
miRNAs; Thymocytes; Development; T-CELL DEVELOPMENT; TARGET GENES; TGF-BETA; DIFFERENTIATION; EXPRESSION; MIR-150; AUTOIMMUNITY; ABSENCE; TRANSCRIPTION; HOMEOSTASIS;
D O I：
10.1159/000496093
中图分类号：
R392 [医学免疫学];
学科分类号：
100102 ;
摘要：
MicroRNAs (miRNAs) are a class of endogenous noncoding single-stranded RNAs widely distributed in eukaryotes, which can modulate target gene expression at posttranscriptional level and participate in cell proliferation, differentiation, and apoptosis. Related studies have shown that miRNAs are instrumental to many aspects of immunity, including various levels of T-cell immunity. In addition, multiple miRNAs have been ascribed key roles in T-cell development, differentiation, and function. In this review, we highlight the current literature regarding the functional role of miRNAs at various stages of thymocyte development. A better understanding of the relationship between miRNAs and thymocyte development is helpful for the exploration of the exact roles of miRNAs in the development and function of the immune system, as well as related clinical diseases. (c) 2019 The Author(s) Published by S. Karger AG, Basel
引用
收藏
页码：315 / 322
页数：8
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