Multiple steps of HLA-G in ovarian carcinoma metastasis: Alter NK cytotoxicity and induce matrix metalloproteinase-15 (MMP-15) expression

被引:44
作者
Lin, Aifen [1 ,2 ]
Xu, Hui-Hui [1 ]
Xu, Dan-Ping [1 ]
Zhang, Xia [2 ]
Wang, Qing [2 ]
Yan, Wei-Hua [1 ,3 ]
机构
[1] Taizhou Hosp Zhejiang Prov, Med Res Ctr, Linhai 317000, Zhejiang, Peoples R China
[2] Taizhou Hosp Zhejiang Prov, Wenzhou Med Coll, Human Tissue Bank, Linhai 317000, Zhejiang, Peoples R China
[3] Wenzhou Med Coll, Minist Educ, Key Lab Lab Med, Wenzhou 325035, Zhejiang, Peoples R China
基金
中国国家自然科学基金;
关键词
LEUKOCYTE ANTIGEN-G; CANCER-CELLS; MEMBRANE; PROGRESSION; TROPHOBLAST; INVASION; MT1-MMP; MT2-MMP; TYPE-1; MODEL;
D O I
10.1016/j.humimm.2012.11.021
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Previous study showed that aberrant HLA-G expression in cancer cells plays important roles in disease progression and it was associated with tumor metastasis and with poor survival in an animal model with ovarian cancer; however, the mechanisms remain to be explored. In this study, we found that HLA-G expression could dramatically decreased the NK cytotoxicity against the ovarian carcinoma cell line (HO-8910) engineered to express HLA-G (HO-8910-G), and matrix metalloproteinase-15 (MMP-15) expression was up-regulated in HO-8910-G cells. Consistent with this, a strong correlation between HLA-G and MMP-15 expression were observed in a cohort of ovarian cancer samples. Knockdown the HLA-G induced MMP-15 expression by small interfere RNA (siRNA) significantly decreased the HO-8910-G cell migration potential and tumor metastasis. Collectively, our study indicated that HLA-G involved in tumor invasiveness or metastasis may rely on the NK cytotoxicity inhibition and induction of MMP-15 expression in ovarian cancer. (C) 2012 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.
引用
收藏
页码:439 / 446
页数:8
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