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Multiple steps of HLA-G in ovarian carcinoma metastasis: Alter NK cytotoxicity and induce matrix metalloproteinase-15 (MMP-15) expression
被引:44
作者:
Lin, Aifen
[1
,2
]
Xu, Hui-Hui
[1
]
Xu, Dan-Ping
[1
]
Zhang, Xia
[2
]
Wang, Qing
[2
]
Yan, Wei-Hua
[1
,3
]
机构:
[1] Taizhou Hosp Zhejiang Prov, Med Res Ctr, Linhai 317000, Zhejiang, Peoples R China
[2] Taizhou Hosp Zhejiang Prov, Wenzhou Med Coll, Human Tissue Bank, Linhai 317000, Zhejiang, Peoples R China
[3] Wenzhou Med Coll, Minist Educ, Key Lab Lab Med, Wenzhou 325035, Zhejiang, Peoples R China
基金:
中国国家自然科学基金;
关键词:
LEUKOCYTE ANTIGEN-G;
CANCER-CELLS;
MEMBRANE;
PROGRESSION;
TROPHOBLAST;
INVASION;
MT1-MMP;
MT2-MMP;
TYPE-1;
MODEL;
D O I:
10.1016/j.humimm.2012.11.021
中图分类号:
R392 [医学免疫学];
Q939.91 [免疫学];
学科分类号:
100102 ;
摘要:
Previous study showed that aberrant HLA-G expression in cancer cells plays important roles in disease progression and it was associated with tumor metastasis and with poor survival in an animal model with ovarian cancer; however, the mechanisms remain to be explored. In this study, we found that HLA-G expression could dramatically decreased the NK cytotoxicity against the ovarian carcinoma cell line (HO-8910) engineered to express HLA-G (HO-8910-G), and matrix metalloproteinase-15 (MMP-15) expression was up-regulated in HO-8910-G cells. Consistent with this, a strong correlation between HLA-G and MMP-15 expression were observed in a cohort of ovarian cancer samples. Knockdown the HLA-G induced MMP-15 expression by small interfere RNA (siRNA) significantly decreased the HO-8910-G cell migration potential and tumor metastasis. Collectively, our study indicated that HLA-G involved in tumor invasiveness or metastasis may rely on the NK cytotoxicity inhibition and induction of MMP-15 expression in ovarian cancer. (C) 2012 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.
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页码:439 / 446
页数:8
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