Multiple steps of HLA-G in ovarian carcinoma metastasis: Alter NK cytotoxicity and induce matrix metalloproteinase-15 (MMP-15) expression

被引：44

作者：

Lin, Aifen ^{[1
,2
]}

Xu, Hui-Hui ^{[1
]}

Xu, Dan-Ping ^{[1
]}

Zhang, Xia ^{[2
]}

Wang, Qing ^{[2
]}

Yan, Wei-Hua ^{[1
,3
]}

机构：

[1] Taizhou Hosp Zhejiang Prov, Med Res Ctr, Linhai 317000, Zhejiang, Peoples R China

[2] Taizhou Hosp Zhejiang Prov, Wenzhou Med Coll, Human Tissue Bank, Linhai 317000, Zhejiang, Peoples R China

[3] Wenzhou Med Coll, Minist Educ, Key Lab Lab Med, Wenzhou 325035, Zhejiang, Peoples R China

来源：

HUMAN IMMUNOLOGY | 2013年 / 74卷 / 04期

基金：

中国国家自然科学基金;

关键词：

LEUKOCYTE ANTIGEN-G; CANCER-CELLS; MEMBRANE; PROGRESSION; TROPHOBLAST; INVASION; MT1-MMP; MT2-MMP; TYPE-1; MODEL;

D O I：

10.1016/j.humimm.2012.11.021

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Previous study showed that aberrant HLA-G expression in cancer cells plays important roles in disease progression and it was associated with tumor metastasis and with poor survival in an animal model with ovarian cancer; however, the mechanisms remain to be explored. In this study, we found that HLA-G expression could dramatically decreased the NK cytotoxicity against the ovarian carcinoma cell line (HO-8910) engineered to express HLA-G (HO-8910-G), and matrix metalloproteinase-15 (MMP-15) expression was up-regulated in HO-8910-G cells. Consistent with this, a strong correlation between HLA-G and MMP-15 expression were observed in a cohort of ovarian cancer samples. Knockdown the HLA-G induced MMP-15 expression by small interfere RNA (siRNA) significantly decreased the HO-8910-G cell migration potential and tumor metastasis. Collectively, our study indicated that HLA-G involved in tumor invasiveness or metastasis may rely on the NK cytotoxicity inhibition and induction of MMP-15 expression in ovarian cancer. (C) 2012 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.

引用

页码：439 / 446

页数：8

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