UV-B-Induced Erythema in Human Skin: The Circadian Clock Is Ticking

被引：19
|
作者：
Sarkar, Soumyadeep [1 ]
Gaddameedhi, Shobhan [1 ,2 ]
机构：
[1] Washington State Univ, Dept Pharmaceut Sci, Coll Pharm, Spokane, WA USA
[2] Washington State Univ, Sleep & Performance Res Ctr, Spokane, WA USA
来源：
JOURNAL OF INVESTIGATIVE DERMATOLOGY | 2018年 / 138卷 / 02期
基金：
美国国家卫生研究院;
关键词：
INDUCED DNA-DAMAGE; CANCER; SUNBURN; RHYTHM; P53;
D O I：
10.1016/j.jid.2017.09.002
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
Acute exposure of skin to UV-B causes DNA damage and sunburn erythema in both mice and humans. Previous studies documented time-of-day-related differences in sunburn responses after UV-B exposure in mice. Because humans are diurnal and mice are nocturnal, the circadian rhythm in human skin was hypothesized to be in opposite phase to the rhythm in mice. A study by Nikkola et al. demonstrates that humans are more prone to sunburn erythema after evening exposure to solar UV-B radiation as compared with morning exposure.
引用
收藏
页码：248 / 251
页数：5
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