Square-Wave Voltammetry as Analytical Tool for Real-Time Study of Controlled Naproxen Releasing from Cellulose Derivative Materials

被引：20

作者：

Fonseca, Wilson T. ^{[1
,2
]}

Santos, Rodrigo F. ^{[2
]}

Alves, Janainne N. ^{[2
]}

Ribeiro, Sabrina D. ^{[2
]}

Takeuchi, Regina M. ^{[1
,2
]}

Santos, Andre L. ^{[1
,2
]}

Assuncao, Rosana M. N. ^{[1
,2
]}

Filho, Guimes R. ^{[2
]}

Munoz, Rodrigo A. A. ^{[2
]}

机构：

[1] Univ Fed Uberlandia, Fac Ciencias Integradas Pontal, BR-38304402 Ituiutaba, MG, Brazil

[2] Univ Fed Uberlandia, Inst Quim, BR-38400902 Uberlandia, MG, Brazil

来源：

ELECTROANALYSIS | 2015年 / 27卷 / 08期

关键词：

Controlled release; Drug delivery; Naproxen; Cellulose acetate; Square-wave voltammetry; GLASSY-CARBON ELECTRODE; PHARMACEUTICAL FORMULATIONS; PASTE ELECTRODE; LIQUID; QUANTIFICATION; NANOTUBES; MATRIX; SENSOR; ASSAY;

D O I：

10.1002/elan.201500011

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

This work reports the successful use of squarewave voltammetry (SWV) to directly assess the controlled releasing profile of naproxen from lab-made cellulose derivative materials (membranes and microparticles) in phosphate buffer (pH 7.4) at 36 degrees C. Particular advantage of SWV refers to the direct real-time monitoring of released drug from cellulose derivative microparticles, which cannot be easily assessed by UV-spectrophotometry. Moreover, SWV was able to detect modifications in the naproxen releasing profile due to morphology and processing of membranes and microparticles. The possible miniaturization and versatility of SWV suggest the promising application on the study of several drug delivery systems, including in vivo studies.

引用

页码：1847 / 1854

页数：8

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