Electrochemical Reduction of Carbamazepine in Ethanol and Water Solutions Using a Glassy Carbon Electrode

被引：0
|
作者：
Atkins, S. [1 ]
Jimenez-Perez, R. [2 ]
Sevilla, J. M. [2 ]
Blazquez, M. [2 ]
Pineda, T. [2 ]
Gonzalez-Rodriguez, J. [1 ]
机构：
[1] Lincoln Univ, Sch Life Sci, Brayford Pool LN6 7TS, Lincoln, England
[2] Univ Cordoba, Dept Quim Fis & Termodinam Aplicada, E-14071 Cordoba, Spain
来源：
INTERNATIONAL JOURNAL OF ELECTROCHEMICAL SCIENCE | 2013年 / 8卷 / 02期
关键词：
Carbamazepine; electrochemical reduction; cyclic voltammetry; differential pulse voltammetry; glassy carbon electrode; DIMETHYLFORMAMIDE; ELECTROREDUCTION; SOLVENT;
D O I：
暂无
中图分类号：
O646 [电化学、电解、磁化学];
学科分类号：
081704 ;
摘要：
The electrochemical reduction of carbamazepine in ethanol and water using a glassy carbon electrode has been studied. In all experimental conditions of scan rate and concentration of carbamazepine an irreversible cathodic wave was observed by cyclic voltammetry (CV). Electrochemical parameters and a plausible EqC mechanism have been reported from the electrochemical measurements and digital simulation. The values of thermodynamic E1/2 were correlated with solvent polarity parameters that it can be interesting for biological, pharmaceutical and forensic purposes. Limits of Detection (LOD) for DPV are 1.1 and 9.0 mu g/mL (4.65x10(-6) and 3.81x10(-5) M) in ethanol and water, respectively. The precision and recoveries obtained for tablets and plasma samples showed that the method could be successfully used for analysis.
引用
收藏
页码：2056 / 2068
页数：13
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