EndoTOFPET-US: a novel multimodal tool for endoscopy and positron emission tomography

被引:27
作者
Aubry, N. [1 ]
Auffray, E. [2 ]
Mimoun, F. B. [2 ]
Brillouet, N. [3 ]
Bugalho, R. [4 ]
Charbon, E. [5 ]
Charles, O. [6 ]
Cortinovis, D. [7 ,8 ]
Courday, P. [3 ]
Cserkaszky, A. [9 ]
Damon, C. [6 ]
Doroud, K. [2 ]
Fischer, J. -M. [9 ]
Fornaro, G. [2 ]
Fourmigue, J. -M. [1 ]
Frisch, B. [2 ]
Fuerst, B. [10 ]
Gardiazabal, J. [10 ]
Gadow, K. [7 ]
Garutti, E. [8 ]
Gaston, C. [4 ]
Gil-Ortiz, A. [11 ]
Guedj, E. [6 ]
Harion, T. [11 ]
Jarron, P. [2 ]
Kabadanian, J. [6 ]
Lasser, T. [10 ]
Laugier, R. [6 ]
Lecoq, P. [2 ]
Lombardo, D. [12 ]
Mandai, S. [5 ]
Mas, E. [12 ]
Meyer, T. [2 ]
Mundler, O. [6 ]
Navab, N. [10 ]
Ortigao, C. [4 ]
Paganoni, M. [13 ]
Perrodin, D. [1 ]
Pizzichemi, M. [13 ]
Prior, J. O. [14 ]
Reichl, T. [10 ]
Reinecke, M. [7 ]
Rolo, M. [4 ]
Schultz-Coulon, H. -C. [11 ]
Schwaiger, M. [15 ]
Shen, W. [11 ]
Silenzi, A. [7 ]
Silva, J. C. [4 ]
Silva, R. [4 ]
Schweiger, I. Somlai [15 ]
机构
[1] Fibercryst SAS, F-69616 Villeurbanne, France
[2] CERN, European Org Nucl Res, CH-1211 Geneva 23, Switzerland
[3] Kloe SA, Hotel Entreprise Millenaire, F-34000 Montpellier, France
[4] Lab Instrumentacao & Fis Expt Particulas, P-1000149 Lisbon, Portugal
[5] Delft Univ Technol, NL-2628 CN Delft, Netherlands
[6] Univ Mediteranee, F-13007 Marseille, France
[7] Deutsch Elektronen Synchrotron DESY, D-22607 Hamburg, Germany
[8] Univ Hamburg, Dept Phys, D-20355 Hamburg, Germany
[9] SurgicEye Gmbh, D-81671 Munich, Germany
[10] Tech Univ Munich, D-85748 Munich, Germany
[11] Heidelberg Univ, Kirchhoff Inst Phys, D-69120 Heidelberg, Germany
[12] Aix Marseille Univ, CRO2, Ctr Rech Oncol Biol & Oncopharmacol, Inserm UMR S 911, F-13005 Marseille, France
[13] Univ Milano Bicocca, I-20126 Milan, Italy
[14] Univ Lausanne Hosp, CH-1011 Lausanne, Switzerland
[15] Tech Univ Munich, Nukl Med Klin & Poliklin, Klinikum Rechts Isar, D-81675 Munich, Germany
关键词
Gamma camera; SPECT; PET PET/CT; coronary CT angiography (CTA); Multi-modality systems; Intra-operative probes;
D O I
10.1088/1748-0221/8/04/C04002
中图分类号
TH7 [仪器、仪表];
学科分类号
0804 ; 080401 ; 081102 ;
摘要
The EndoTOFPET-US project aims to develop a multimodal detector to foster the development of new biomarkers for prostate and pancreatic tumors. The detector will consist of two main components: an external plate, and a PET extension to an endoscopic ultrasound probe. The external plate is an array of LYSO crystals read out by silicon photomultipliers (SiPM) coupled to an Application Specific Integrated Circuit (ASIC). The internal probe will be an highly integrated and miniaturized detector made of LYSO crystals read out by a fully digital SiPM featuring photosensor elements and digital readout in the same chip. The position and orientation of the two detectors will be tracked with respect to the patient to allow the fusion of the metabolic image from the PET and the anatomic image from the ultrasound probe in the time frame of the medical procedure. The fused information can guide further interventions of the organ, such as biopsy or in vivo confocal microscopy.
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页数:8
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