Phosphonate lipid tubules II

被引：67

作者：

Thomas, BN ^{[1
]}

Lindemann, CM

Corcoran, RC

Cotant, CL

Kirsch, JE

Persichini, PJ

机构：

[1] Louisiana State Univ, Dept Chem, Baton Rouge, LA 70803 USA

[2] Merck & Co Inc, Rahway, NJ 07065 USA

[3] Univ Wyoming, Dept Chem, Laramie, WY 82071 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2002年 / 124卷 / 07期

关键词：

D O I：

10.1021/ja012137a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We describe a new chiral tubule-forming lipid in which the C-O-P phosphoryl linkage of the archetypal tubule-forming molecule, 1,2-bis(10,12-tricosadiynoyl)-sn-glycero-3-phosphocholine, "DC(8,9)PC", is replaced by a C-P linkage. Tubule formation with this phosphonate analogue proceeds under the same mild conditions as with DC(8,9)PC and produces similar yields, but synchrotron small-angle X-ray scattering, atomic force microscopy, and optical microscopy show the new tubules to have diameters 1.94 times as great, to be significantly shorter, and to be thinner-walled. A significant portion of the enantiomerically pure chiral phosphonate precipitate is in the form of stable open helices, and these helices are divided almost evenly between left- and right-handed members.

引用

页码：1227 / 1233

页数：7

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