Targeting Epidermal Growth Factor Receptor with Ferrocene-Based Kinase Inhibitors

被引：20
作者：
Amin, Jahangir [1 ]
Chuckowree, Irina [1 ]
Tizzard, Graham J. [2 ]
Coles, Simon J. [2 ]
Wang, Minghua [3 ]
Bingham, John P. [4 ]
Hartley, John A. [4 ]
Spencer, John [1 ]
机构：
[1] Univ Sussex, Sch Life Sci, Dept Chem, Brighton BN1 9QJ, E Sussex, England
[2] Univ Southampton, Sch Chem, UK Natl Crystallog Serv, Southampton SO17 1BJ, Hants, England
[3] Univ Toronto, Terrence Donnelly Ctr Cellular & Biomol Res, Toronto, ON M5S 3E1, Canada
[4] UCL Canc Inst, CRUK Drug DNA Interact Res Grp, London WC1E 6DD, England
来源：
ORGANOMETALLICS | 2013年 / 32卷 / 02期
基金：
英国工程与自然科学研究理事会;
关键词：
ORGANOMETALLIC COMPOUNDS; BIOLOGICAL-ACTIVITY; DRUG; ACTIVATION; REDUCTION; MECHANISM; COMPLEX; PROTEIN; DESIGN;
D O I：
10.1021/om300974d
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
A series of ferrocene analogues based on a 6,7-dimethoxy-N-phenylquinazolin-4-amine template has been synthesized, and two compounds were characterized in the solid state by X-ray crystallography. The compounds have been tested for in vitro anticancer activity, against epidermal growth receptor (EGFR), and submicromolar IC50 values have been determined.
引用
收藏
页码：509 / 513
页数：5
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