Quality control mechanisms in cellular and systemic DNA damage responses

被引：14
作者：
Ermolaeva, Maria A. [1 ,2 ]
Dakhovnik, Alexander [1 ,2 ]
Schumacher, Bjoern [1 ,2 ]
机构：
[1] Univ Cologne, Fac Med, Inst Genome Stabil Ageing & Dis, D-50931 Cologne, Germany
[2] Univ Cologne, Cologne Excellence Cluster Cellular Stress Respon, D-50931 Cologne, Germany
来源：
AGEING RESEARCH REVIEWS | 2015年 / 23卷
基金：
欧洲研究理事会;
关键词：
DNA damage; Ageing; Ubiquitin proteasome system; DNA repair; Progeroid syndromes; Genome stability; NUCLEOTIDE EXCISION-REPAIR; RNA-POLYMERASE-II; STRAND BREAK REPAIR; C. ELEGANS HOMOLOG; FANCONI-ANEMIA; INDUCED UBIQUITINATION; PROTEIN; TRANSCRIPTION; PCNA; P53;
D O I：
10.1016/j.arr.2014.12.009
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The maintenance of the genome is of pivotal importance for the functional integrity of cells and tissues. The gradual accumulation of DNA damage is thought to contribute to the functional decline of tissues and organs with ageing. Defects in multiple genome maintenance systems cause human disorders characterized by cancer susceptibility, developmental failure, and premature ageing. The complex pathological consequences of genome instability are insufficiently explained by cell-autonomous DNA damage responses (DDR) alone. Quality control pathways play an important role in DNA repair and cellular DDR pathways. Recent years have revealed non-cell autonomous effects of DNA damage that impact the physiological adaptations during ageing. We will discuss the role of quality assurance pathways in cell-autonomous and systemic responses to genome instability. (C) 2015 Elsevier B.V. All rights reserved.
引用
收藏
页码：3 / 11
页数：9
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