Quality control mechanisms in cellular and systemic DNA damage responses

被引：13
|
作者：
Ermolaeva, Maria A. [1 ,2 ]
Dakhovnik, Alexander [1 ,2 ]
Schumacher, Bjoern [1 ,2 ]
机构：
[1] Univ Cologne, Fac Med, Inst Genome Stabil Ageing & Dis, D-50931 Cologne, Germany
[2] Univ Cologne, Cologne Excellence Cluster Cellular Stress Respon, D-50931 Cologne, Germany
来源：
AGEING RESEARCH REVIEWS | 2015年 / 23卷
基金：
欧洲研究理事会;
关键词：
DNA damage; Ageing; Ubiquitin proteasome system; DNA repair; Progeroid syndromes; Genome stability; NUCLEOTIDE EXCISION-REPAIR; RNA-POLYMERASE-II; STRAND BREAK REPAIR; C. ELEGANS HOMOLOG; FANCONI-ANEMIA; INDUCED UBIQUITINATION; PROTEIN; TRANSCRIPTION; PCNA; P53;
D O I：
10.1016/j.arr.2014.12.009
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The maintenance of the genome is of pivotal importance for the functional integrity of cells and tissues. The gradual accumulation of DNA damage is thought to contribute to the functional decline of tissues and organs with ageing. Defects in multiple genome maintenance systems cause human disorders characterized by cancer susceptibility, developmental failure, and premature ageing. The complex pathological consequences of genome instability are insufficiently explained by cell-autonomous DNA damage responses (DDR) alone. Quality control pathways play an important role in DNA repair and cellular DDR pathways. Recent years have revealed non-cell autonomous effects of DNA damage that impact the physiological adaptations during ageing. We will discuss the role of quality assurance pathways in cell-autonomous and systemic responses to genome instability. (C) 2015 Elsevier B.V. All rights reserved.
引用
收藏
页码：3 / 11
页数：9
相关论文
共 50 条
  • [1] Cellular responses to DNA damage
    Wang, JYJ
    CURRENT OPINION IN CELL BIOLOGY, 1998, 10 (02) : 240 - 247
  • [2] Cellular responses to DNA damage
    Norbury, CJ
    Hickson, ID
    ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, 2001, 41 : 367 - 401
  • [3] CELLULAR-RESPONSES TO DNA DAMAGE
    WALKER, GC
    MARSH, L
    DODSON, L
    ENVIRONMENTAL HEALTH PERSPECTIVES, 1985, 62 (OCT) : 115 - 117
  • [4] The p53 network: cellular and systemic DNA damage responses in aging and cancer
    Reinhardt, H. Christian
    Schumacher, Bjoern
    TRENDS IN GENETICS, 2012, 28 (03) : 128 - 136
  • [5] The p53 network: cellular and systemic DNA damage responses in cancer and aging
    Vaddavalli, Pavana Lakshmi
    Schumacher, Bjoern
    TRENDS IN GENETICS, 2022, 38 (06) : 598 - 612
  • [6] Early cellular responses to genotoxic stress: DNA damage-dependent and -independent mechanisms
    Fritz, G
    Kaina, B
    NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 2003, 367 : R152 - R152
  • [7] Investigating mechanisms of cellular adaptation to DNA damage
    Kelly, JW
    Talbot, KR
    Lloyd, DR
    MUTAGENESIS, 2004, 19 (06) : 516 - 516
  • [8] DNA Damage by Radiopharmaceuticals and Mechanisms of Cellular Repair
    Monfared, Yousef Khazaei
    Heidari, Pedram
    Klempner, Samuel J.
    Mahmood, Umar
    Parikh, Aparna R.
    Hong, Theodore S.
    Strickland, Matthew R.
    Esfahani, Shadi A.
    PHARMACEUTICS, 2023, 15 (12)
  • [9] Systemic DNA damage responses in aging and diseases
    Ribezzo, Flavia
    Shiloh, Yosef
    Schumacher, Bjoern
    SEMINARS IN CANCER BIOLOGY, 2016, 37-38 : 26 - 35
  • [10] SUMO conjugation and cellular responses to DNA damage
    Biornsti, M. A.
    Placzek, W.
    Wright, C.
    Whitaker, R.
    Onuiri, J.
    EUROPEAN JOURNAL OF CANCER, 2016, 69 : S75 - S75
12345