Thienopyrrole-expanded BODIPY as a potential NIR photosensitizer for photodynamic therapy

被引：187

作者：

Yang, Yongchao ^{[1
]}

Guo, Qiuli ^{[1
]}

Chen, Huachao ^{[1
]}

Zhou, Zhikuan ^{[1
]}

Guo, Zijian ^{[1
]}

Shen, Zhen ^{[1
]}

机构：

[1] Nanjing Natl Lab Microstruct, State Key Lab Coordinat Chem, Nanjing 210093, Jiangsu, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2013年 / 49卷 / 38期

基金：

中国国家自然科学基金;

关键词：

SINGLET-OXYGEN GENERATION; TUNABLE FLUORESCENT DYES; RESTRICTED AZA-BODIPY; HIGHLY FLUORESCENT; IN-VITRO; BASIC PRINCIPLES; CHARGE-TRANSFER; ENERGY-TRANSFER; EFFICIENT; PORPHYRIN;

D O I：

10.1039/c3cc40746b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The synthesis and characterization of a highly photostable bromo-substituted BODIPY dye (I) fused-ring-expanded with thienopyrrole moieties is reported. The results of MTT assays and flow cytometric analyses in living HeLa cells demonstrate that I has a high singlet oxygen quantum yield (Phi(Delta) = 0.63) and exhibits photocytotoxicity upon irradiation in the NIR region making it potentially suitable for use in PDT.

引用

页码：3940 / 3942

页数：3

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