Oxazolidinones: New antibacterial agents

被引：57
作者：
Ford, CW
Hamel, JC
Stapert, D
Moerman, JK
Hutchinson, DK
Barbachyn, MR
Zurenko, GE
机构：
[1] Pharmacia and Upjohn Inc., Kalamazoo, MI 49001
来源：
TRENDS IN MICROBIOLOGY | 1997年 / 5卷 / 05期
关键词：
D O I：
10.1016/S0966-842X(97)01032-9
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The oxazolidinones are a new chemical class of synthetic antibacterial agents that are active orally or intravenously against multidrug-resistant Gram-positive bacteria. Their unique mechanism of action and activity against bacteria that pose therapeutic problems in hospital and community treatments make them promising candidates for antimicrobial agents.
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收藏
页码：196 / 200
页数：5
相关论文
共 30 条
[1]   WORLDWIDE DEVELOPMENT OF ANTIBIOTIC-RESISTANCE IN PNEUMOCOCCI [J].
APPELBAUM, PC .
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, 1987, 6 (04) :367-377
[2]   INVITRO EVALUATION OF DUP-105 AND DUP-721, 2 NEW OXAZOLIDINONE ANTIMICROBIAL AGENTS [J].
BARRY, AL .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1988, 32 (01) :150-152
[3]   EMERGENCE OF DRUG-RESISTANT PNEUMOCOCCAL INFECTIONS IN THE UNITED-STATES [J].
BREIMAN, RF ;
BUTLER, JC ;
TENOVER, FC ;
ELLIOTT, JA ;
FACKLAM, RR .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1994, 271 (23) :1831-1835
[4]  
Brickner SJ, 1996, CURR PHARM DESIGN, V2, P175
[5]   Synthesis and antibacterial activity of U-100592 and U-100766, two oxazolidinone antibacterial agents for the potential treatment of multidrug-resistant Gram-positive bacterial infections [J].
Brickner, SJ ;
Hutchinson, DK ;
Barbachyn, MR ;
Manninen, PR ;
Ulanowicz, DA ;
Garmon, SA ;
Grega, KC ;
Hendges, SK ;
Toops, DS ;
Ford, CW ;
Zurenko, GE .
JOURNAL OF MEDICINAL CHEMISTRY, 1996, 39 (03) :673-679
[6]   INVITRO MICROBIOLOGICAL ACTIVITIES OF DUP-105 AND DUP-721, NOVEL SYNTHETIC OXAZOLIDINONES [J].
BRUMFITT, W ;
HAMILTONMILLER, JMT .
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1988, 21 (06) :711-720
[7]   ANTIBACTERIAL OXAZOLIDINONES - INVITRO ACTIVITY OF A NEW ANALOG, E3709 [J].
BRUMFITT, W ;
HAMILTONMILLER, JMT .
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE, 1992, 15 (07) :621-625
[8]   MECHANISM OF ACTION AND INVITRO AND INVIVO ACTIVITIES OF S-6123, A NEW OXAZOLIDINONE COMPOUND [J].
DALY, JS ;
ELIOPOULOS, GM ;
WILLEY, S ;
MOELLERING, RC .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1988, 32 (09) :1341-1346
[9]   ACTIVITY AND MECHANISM OF ACTION OF DUP-105 AND DUP-721, NEW OXAZOLIDINONE COMPOUNDS [J].
DALY, JS ;
ELIOPOULOS, GM ;
REISZNER, E ;
MOELLERING, RC .
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1988, 21 (06) :721-730
[10]   In vitro activities of new oxazolidinone antimicrobial agents against enterococci [J].
Eliopoulos, GM ;
Wennersten, CB ;
Gold, HS ;
Moellering, RC .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1996, 40 (07) :1745-1747
123